ULTRASOUND NEUROMODULATION TREATMENT OF CLINICAL CONDITIONS

• US 20140343463A1
• Filed: 05/20/2013
• Published: 11/20/2014
• Est. Priority Date: 05/20/2013
• Status: Abandoned Application

• Current Assignee: David J. Mishelevich
• Original Assignee: David J. Mishelevich
• Inventors: Mishelevich, David J.
• Application Number:
  US13/898,401
• Publication Number:
  US 20140343463A1
• Time in Patent Office: Days
• US Class Current: 601/2
• CPC Class Codes: A61N 2007/0026 Stimulation of nerve tissue
• CPC Class Codes: A61N 2007/0065 Concave transducers
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

Disclosed are methods and systems for non-invasive ultrasound neuromodulation of neural targets for the treatment of clinical conditions. These include neuromodulation of the occipital nerves to treat migraine and cluster headaches in their multiple variations as well other pain and tension conditions, the Sphenopalatine Ganglion and associated neural structures vidian nerve and/or sphenopalatine nerve to treat migraine and cluster headaches as well as other indications such as neurologic and psychiatric conditions, and the Reticular Activating System for a variety of clinical purposes such as reversibly putting a patient to sleep or waking them up (for example, for the purpose of anesthesia) or reversibly putting a patient into a coma (for example for the purpose of protecting or rehabilitating the brain of the patient after a stroke or head injury). Other clinical applications include neuromodulation of the Motor Cortex and other areas of the brain impacted by stroke for mitigating the effects of stroke and/or in stroke rehabilitation, pain-related targets to treat acute or chronic pain, tinnitus-related targets to treat that condition, and targets for the treatment of Post-Traumatic Stress Disorder. Use of ultrasound neuromodulation in sessions can enhance the effects.

Claims

1. A method of non-invasively neuromodulating the target occipital nerves using ultrasound stimulation, the method comprising:

aiming an ultrasound transducer at the target,

applying pulsed power to said ultrasound transducer via a control circuit thereby modulating the activity of the target, and

applying the neuromodulation in sessions,

whereby therapeutic results are obtained.

2. The method of claim 1, wherein the neural target is comprised of one or a plurality of the occipital nerves.

3. The method of claim 2, wherein the disorder treated is selected from the group consisting of headaches in various forms, migraine headaches in various forms, cluster headaches in various forms, neuralgias, facial and other pain or tension syndromes.

4. The method of claim 2, wherein the ultrasound neuromodulation results in activation of the hypothalami, the thalami, the orbito-frontal cortex, the prefrontal cortex, periaqueductal gray, the inferior parietal lobe, and the cerebellum.

5. The method of claim 2, wherein the ultrasound neuromodulation results in deactivation of the primary motor area (M1) the primary visual area (V1), the primary auditory area (A1), and the somatosensory (S1), the amygdala, the paracentral lobule, the hippocampus, the secondary somatosensory area (S2), and the supplementary motor area (SMA).

6. The method of claim 2, wherein the neuromodulation of the occipital nerves is selected from the group consisting of unilateral and bilateral.

7. The method of claim 1, further comprising focusing the sound field of an ultrasound transducer at the target Sphenopalatine Ganglion and associated structures neuromodulating the activity of the target in a manner selected from the group of up-regulation, down-regulation.

8. The method of claim 7, wherein the disorder treated is selected from the group consisting of headaches in various forms, migraine headaches in various forms, cluster headaches in various forms, neuralgias, other pain syndromes, movement and muscular disorders, epilepsy, hypertension, cerebral vascular disorders including stroke, autoimmune diseases, sleep disorders, asthma, metabolic disorders, addiction, autonomic disorders (including, but not limited to cardiovascular disorders, gastrointestinal disorders, genitourinary disorders), and neuropsychiatric disorders.

9. The method of claim 1 where the neural structure is the Reticular Activating System, wherein the neuromodulation manner is selected from the group of up-regulation and down-regulation.

10. The method of claim 9, wherein the clinical function is selected from the group consisting of:

reversibly putting a patient to sleep or waking them up and reversibly putting a patient into a coma.

11. The method of claim 9, wherein the clinical purpose is selected from the group consisting of:

anesthesia, protecting or rehabilitating the brain after a stroke, and protecting or rehabilitating the brain after head trauma.

12. The method of claim 1 wherein the condition treated is selected from the group consisting of stroke mitigation and stroke rehabilitation.

13. The method of claim 12, wherein the one or a plurality of stroke-related targets is selected from the group consisting Primary Motor Cortex, Primary Sensory Cortex, Wernicke'"'"'s Area, posterior limb of internal capsule, basis pontis, corona radiate, and other neural centers.

14. The method of claim 12, wherein the clinical function is selected from the group consisting of exciting the motor cortex ipsilateral to the brain lesion and inhibiting the motor cortex contralateral to the brain region.

15. The method of claim 12, wherein the location of the stroke is selected from the group consisting of cortical, subcortical, and brainstem.

16. The method of claim 12, wherein the cause of the stroke is selected from the group consisting of ischemic and hemorrhagic.

17. The method of claim 12 where neuromodulation for stroke is combined with the neuromodulation of the Reticular Activating System to keep the general level of brain and base central activity up to prevent Central Nervous System failure.

18. The method of claim 1, wherein the step of aiming comprising orienting the ultrasound transducer and focusing the ultrasound so that it hits one or a plurality of pain-related neural targets selected from the group consisting of orbitofrontal cortex, Rostral Anterior Cingulate Cortex and Dorsal Anterior Cingulate Gyms, insula, amygdala, thalamus, hypothalamus, and hippocampus.

19. The method of claim 1, further comprising aiming an ultrasound transducer neuromodulating tinnitus-related neural targets in a manner selected from the group of up-regulation, down-regulation.

20. The method of claim 1, wherein one or a plurality of Post Traumatic Syndrome Disorders-related targets are selected from the group consisting of Orbito-Frontal Cortex, Anterior Cingulate Cortex, Insula, Amygdala, and Hippocampus.