SYSTEMS, DEVICES, AND METHODS FOR TRANSDERMAL DELIVERY
2 Assignments
0 Petitions
Accused Products
Abstract
Disclosed herein are systems, devices, and methods for transdermal delivery of a therapeutic agent (for example, a molecule or molecules) to a therapy site. The systems, devices, and methods described herein are flexible and able to conform to the contours of a therapy site, such as the shape of a user'"'"'s face. In certain approaches, the devices and systems described herein include an integrated power supply for standalone application to the therapy site. The devices, systems, and methods include flexible electrodes with integrated conductance layers and interface layers for improved stability and current distribution. In practice, the device includes at least two electrodes which are coupled to the therapy site. When the electrodes are placed at the therapy site, they are electrically coupled, thereby drawing a current from the power supply to deliver the therapeutic agent to the therapy site.
15 Citations
69 Claims
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18. A device for transdermal drug delivery, comprising:
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a power supply having a first terminal and a second terminal; a first electrode having a first interface layer integrally coupled to a first conductance layer, wherein the first conductance layer is electrically coupled to the first terminal of the power supply; a second electrode having a second interface layer integrally coupled to a second conductance layer, wherein the second conductance layer is electrically coupled to the second terminal of the power supply; a base, wherein the first electrode, second electrode, and power supply are coupled to the base, and wherein the first electrode and second electrode are spaced apart by a separation channel; and a first coupling layer coupled to the first interface layer and a second coupling layer coupled to the second interface layer, wherein the first coupling layer and second coupling layer are spaced apart by the separation channel. - View Dependent Claims (19, 20)
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21. The device of 20, wherein the therapeutic agent includes a plurality of therapeutic molecules, an ionic therapeutic molecule, a charged therapeutic molecule, a peptide, a vitamin, or a plant extract.
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23. A device for transdermal drug delivery, comprising:
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a power supply having a first terminal and a second terminal; a first electrode having a first interface layer integrally coupled to a first conductance layer, wherein the first conductance layer is electrically coupled to the first terminal of the power supply; a second electrode having a second interface layer integrally coupled to a second conductance layer, wherein the second conductance layer is electrically coupled to the second terminal of the power supply;
a base, wherein the first electrode, second electrode, and power supply are coupled to the base, and wherein the first electrode and second electrode are spaced apart by a separation channel;a first coupling layer coupled to the first interface layer and a second coupling layer coupled to the second interface layer, wherein the first coupling layer and second coupling layer are spaced apart by the separation channel; a spacing layer coupled to the base and the power supply; and an electronics layer. - View Dependent Claims (24, 26, 27, 28, 29, 30, 31, 32, 33)
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36. A kit for transdermal delivery of a therapeutic molecule to a therapy site, comprising:
- a transdermal drug delivery device; and
a serum wherein the serum comprises a therapeutic molecule.
- a transdermal drug delivery device; and
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37. A method for delivering a therapeutic molecule to a therapy site, comprising:
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providing a flexible delivery device having a power supply, a first electrode, and a second electrode, wherein the first electrode and second electrode are spaced apart by a separation channel; applying a serum containing a therapeutic molecule to a therapy site; and placing the first electrode and the second electrode on the therapy site to electrically couple the first electrode and the second electrode, thereby drawing a current from the power supply to deliver the therapeutic molecule to the therapy site. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44)
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Specification