INTRA-ABDOMINAL PRESSURE TO PROMOTE HEMOSTASIS AND SURVIVAL

• US 20150012031A1
• Filed: 08/08/2014
• Published: 01/08/2015
• Est. Priority Date: 08/12/2011
• Status: Active Grant

• Current Assignee: Arsenal Medical, Inc
• Original Assignee: Adam Rago
• Inventors: Marini, John, Helmick, Marc, Sharma, Upma, RAGO, Adam, Zugates, Gregory T.
• Granted Patent: US 9,522,215 B2
• Time in Patent Office: Days
• US Class Current: 606/191
• CPC Class Codes: A61L 24/0036 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures.

Claims

1. A method of treating a hemorrhage within a cavity, comprising the steps of:

applying a pressure to an interior boundary of the cavity, wherein the pressure is characterized by a transient peak value and at least one steady state value.

2. The method of claim 1, wherein the transient peak value less than about 84 mmHg.

3. The method of claim 1, wherein the transient peak value is at least about 51 mmHg.

4. The method of claim 1, wherein the transient peak value is at least about 20 mmHg

5. The method of claim 1, wherein the steady state value is at least about 28 mmHg.

6. The method of claim 1, wherein the steady state value is at least about 14 mmHg.

7. The method of claim 1, wherein the transient peak value occurs within the first three minutes and is followed by the steady state value.

8. The method of claim 7, wherein the steady state value is at least 30% of the transient peak value.

9. The method of claim 7, wherein the steady state value is at least 50% of the transient peak value.

10. The method of claim 7, wherein the steady state value is at least 90% of the transient peak value.

11. The method of claim 1, wherein the pressure is applied by an article placed into the cavity.

12. The method of claim 11, wherein the article is a foam, which is formed inside of the cavity by applying a formulation comprising at least one liquid phase into the cavity.

13. The method of claim 1, wherein the cavity is an abdominal cavity, a junctional hemorrhage, a cavity associated with a pelvic hemorrhage, or a pseudocavity.

14. A kit for treating hemorrhage in a cavity of a patient, the kit comprising:

a formulation comprising at least one liquid phase, the formulation configured to form a foam when disposed into the cavity; and

instructions instructing a user to perform the method of claim 1.

15. The kit of claim 14, wherein the foam is configured to apply a pressure to an interior boundary of a body cavity, the pressure being characterized by a transient peak value followed by a steady state value.

16. The kit of claim 15, wherein the transient peak value is less than about 84 mmHg.

17. The kit of claim 15, wherein the transient peak value is at least about 20 mmHg.

18. The kit of claim 15, wherein the steady state value is at least about 28 mmHg.

19. The kit of claim 15, wherein the steady state value is at least about 14 mmHg.