ANTIMICROBIAL-COATED MEDICAL ARTICLES
First Claim
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1. An article comprising:
- a coating composition comprising a vinyl polymer having a plurality of pendant groups comprisinga first pendant group comprising a cationic component selected from the group consisting of a quaternary amine component, protonated tertiary amine component, and a protonated secondary amine component;
a second pendant group comprising a nonpolar component; and
a third pendant group comprising a first organosilicon component; and
a medical device comprising an elastomeric first substrate having a patient-contact first surface and a second surface;
wherein the vinyl polymer is durably adhered to the patient-contact first surface, andwherein the composition is essentially free of inorganic filler.
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Abstract
The disclosure provides polymers having antimicrobial activity and articles with the polymers coated thereon. The polymers include a first pendant group comprising a first cationic component, a second pendant group comprising a nonpolar component, and a third pendant group comprising an organosilane component. The disclosure also includes methods of coating medical device articles and body fluid-receiving substrates with the antimicrobial polymers. The methods further include the use of adhesion-promoting components.
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Citations
58 Claims
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1. An article comprising:
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a coating composition comprising a vinyl polymer having a plurality of pendant groups comprising a first pendant group comprising a cationic component selected from the group consisting of a quaternary amine component, protonated tertiary amine component, and a protonated secondary amine component; a second pendant group comprising a nonpolar component; and a third pendant group comprising a first organosilicon component; and a medical device comprising an elastomeric first substrate having a patient-contact first surface and a second surface; wherein the vinyl polymer is durably adhered to the patient-contact first surface, and wherein the composition is essentially free of inorganic filler. - View Dependent Claims (4, 6, 7, 8, 9, 10, 11, 15, 17)
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2-3. -3. (canceled)
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5. (canceled)
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12-14. -14. (canceled)
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16. (canceled)
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18-19. -19. (canceled)
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20. An article comprising:
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a coating composition comprising a vinyl polymer having a plurality of pendant groups comprising a first pendant group comprising a cationic component selected from the group consisting of a quaternary amine component, protonated tertiary amine component, and a protonated secondary amine component; a second pendant group comprising a nonpolar component; and a third pendant group comprising a first organosilicon component; and an elastomeric body fluid-contacting substrate having a body fluid-contacting first surface and a second surface; wherein the vinyl polymer is durably adhered to the body fluid-contacting first surface, and wherein the composition is essentially free of inorganic filler. - View Dependent Claims (23, 25, 26, 27, 28, 29, 30, 34)
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21-22. -22. (canceled)
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24. (canceled)
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31-33. -33. (canceled)
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35-37. -37. (canceled)
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38. A method of making a coated article, the method comprising:
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forming a first coating composition comprising a vinyl polymer having a plurality of pendant groups comprising a first pendant group comprising a first cationic component; a second pendant group comprising a nonpolar component; a third pendant group comprising a first organosilicon component; wherein the first coating composition is essentially free of inorganic filler; and contacting the first coating composition with a first surface of a first substrate under conditions suitable to adhere the polymer to the first surface; wherein the first substrate comprises an elastomeric component of a medical device or an elastomeric body fluid-contacting substrate.
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39-56. -56. (canceled)
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57. A medical device article comprising a coating wherein the coating is derived from:
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a composition comprising a free silane component and a vinyl polymer having a plurality of pendant groups comprising a first pendant group comprising a first quaternary ammonium component; a second pendant group comprising a first organosilicon component; wherein the vinyl polymer is durably adhered to the surface of the article.
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58-60. -60. (canceled)
Specification