Gas Exchanger and Artificial Lung

• US 20150024374A1
• Filed: 07/15/2014
• Published: 01/22/2015
• Est. Priority Date: 07/16/2013
• Status: Active Grant

• Current Assignee: Nano2cure Limited
• Original Assignee: Yoram Palti
• Inventors: Palti, Yoram
• Granted Patent: US 9,138,522 B2
• Time in Patent Office: Days
• US Class Current: 435/2
• CPC Class Codes: A61M 1/1698 Blood oxygenators with or without heat-exchangers intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2202/0225 Carbon oxides, e.g. Carbon dioxide
• CPC Class Codes: B01D 69/04 Tubular membranes

Abstract

Blood or other fluids can be caused to interact with a gas by providing a plurality of fluid flow channels that are surrounded by nanotubes, each of the channels having an inflow end and an outflow end, wherein each of the channels is wide enough for the blood to flow through, and wherein the nanotubes are spaced close enough to each other to retain the fluid within the channels when the blood is flowing through the channels. The fluid is then passed through the through the channels while a gas is passed through the spaces between the nanotubes outside the fluid flow channels. This permits the gas to interact with the fluid in the channels.

Claims

1. A gas exchange unit for processing blood that includes blood cells and plasma, the gas exchange unit comprising:

a substrate having a first side and a second side;

a plurality of nanotubes disposed on the second side of the substrate with spaces between the nanotubes, wherein the nanotubes are disposed on the substrate in a configuration that leaves a plurality of blood flow channels that are surrounded by the nanotubes, each of the channels having an inflow end and an outflow end, wherein each of the channels is wide enough for the blood to flow through, and wherein the nanotubes are spaced close enough to each other to retain the plasma within the channels when the blood is flowing through the channels, and wherein the substrate has a plurality of perforations that extend between the first side of the substrate and the second side of the substrate, each of the perforations being aligned with a respective one of the channels;

a blood inlet configured to supply blood to the first side of the substrate, wherein the blood inlet is in fluid communication with the perforations such that blood that arrives via the blood inlet will flow through the perforations and continue on through the channels;

a blood outlet configured to accept blood that arrives from the outflow end of the channels; and

a housing configured to house the substrate and the array of nanotubes, the housing having a gas inlet configured to route a gas into the spaces between the nanotubes and a gas outlet configured to route the gas away from the spaces between the nanotubes.

2. The gas exchange unit of claim 1, wherein each of the nanotubes is perpendicular to the substrate and wherein each of the channels is perpendicular to the substrate.

3. The gas exchange unit of claim 1, wherein the nanotubes are disposed on the substrate in an array configuration, with a plurality of voids in the array, wherein each of the voids corresponds to a respective channel.

4. The gas exchange unit of claim 1, wherein each of the channels has a diameter between 2 and 500 μ

m.

5. The gas exchange unit of claim 1, wherein the nanotubes have a diameter between 5 and 20 nm.

6. The gas exchange unit of claim 1, wherein the nanotubes are spaced on centers that are between 1.5 times the diameter of the nanotubes and 5 times the diameter of the nanotubes.

7. The gas exchange unit of claim 1, wherein each of the nanotubes is perpendicular to the substrate, each of the channels is perpendicular to the substrate, each of the channels has a diameter between 2 and 500 μ

m, and the nanotubes have a diameter between 5 and 20 nm.

8. The gas exchange unit of claim 7, wherein the nanotubes are spaced on centers that are between 1.5 times the diameter of the nanotubes and 5 times the diameter of the nanotubes.

9. The gas exchange unit of claim 8, wherein the nanotubes are disposed on the substrate in an array configuration, with a plurality of voids in the array, wherein each of the voids corresponds to a respective channel.

10. A gas exchanger for processing blood that Includes blood cells and plasma, the gas exchanger comprising:

a plurality of gas exchange units, each of the gas exchange units including (a) a substrate having a first side and a second side, (b) a plurality of nanotubes disposed on the second side of the substrate with spaces between the nanotubes, wherein the nanotubes are disposed on the substrate in a configuration that leaves a plurality of blood flow channels that are surrounded by the nanotubes, each of the channels having an inflow end and an outflow end, wherein each of the channels is wide enough for the blood to flow through, and wherein the nanotubes are spaced close enough to each other to retain the plasma within the channels when the blood is flowing through the channels, and wherein the substrate has a plurality of perforations that extend between the first side of the substrate and the second side of the substrate, each of the perforations being aligned with a respective one of the channels, (c) a blood inlet configured to supply blood to the first side of the substrate, wherein the blood inlet is in fluid communication with the perforations such that blood that arrives via the blood inlet will flow through the perforations and continue on through the channels, and (d) a blood outlet configured to accept blood that arrives from the outflow end of the channels;

a housing configured to house the plurality of gas exchange units, the housing having a gas inlet configured to route a gas into the spaces between the nanotubes, and a gas outlet configured to route the gas away from the spaces between the nanotubes; and

a blood inflow path configured to route incoming blood to at least one of the gas exchange units; and

a blood outflow path configured to route outgoing blood from at least one of the gas exchange units.

11. The gas exchanger of claim 10, wherein the gas exchange units are interconnected so that the blood flows through the gas exchange units in series.

12. The gas exchanger of claim 11 wherein, in each of the gas exchange units, each of the nanotubes is perpendicular to the substrate, each of the channels is perpendicular to the substrate, each of the channels has a diameter between 2 and 500 μ

m, and the nanotubes have a diameter between 5 and 20 nm.

13. The gas exchanger of claim 12 wherein, in each of the gas exchange units, the nanotubes are disposed on the substrate in an array configuration, with a plurality of voids in the array, with each of the voids corresponding to a respective channel.

14. The gas exchanger of claim 10, wherein the gas exchange units are interconnected so that the blood flows through the gas exchange units in parallel.

15. A method for processing blood that includes blood cells and plasma, the method comprising the steps of:

providing a plurality of blood flow channels that are surrounded by nanotubes, each of the channels having an inflow end and an outflow end, wherein each of the channels is wide enough for the blood to flow through, and wherein the nanotubes are spaced close enough to each other to retain the plasma within the channels when the blood is flowing through the channels;

passing blood through the through the channels; and

passing a gas through the spaces between the nanotubes outside the blood flow channels,

wherein the gas interacts with the blood in the channels.

16. The method of claim 15, wherein each of the channels has a diameter between 2 and 500 μ

m.

17. The method of claim 16, wherein the nanotubes have a diameter between 5 and 20 nm.

18. The method of claim 17, wherein the nanotubes are spaced on centers that are between 1.5 times the diameter of the nanotubes and 5 times the diameter of the nanotubes.

19. An apparatus comprising:

a substrate having a first side and a second side;

a plurality of nanotubes disposed on the second side of the substrate with spaces between the nanotubes, wherein the nanotubes are disposed on the substrate in a configuration that leaves a plurality of fluid flow channels that are surrounded by the nanotubes, each of the channels having an inflow end and an outflow end, wherein each of the channels is wide enough for a fluid to flow through, and wherein the nanotubes are spaced close enough to each other to retain the fluid within the channels when the fluid is flowing through the channels, and wherein the substrate has a plurality of perforations that extend between the first side of the substrate and the second side of the substrate, each of the perforations being aligned with a respective one of the channels;

a fluid inlet configured to supply fluid to the first side of the substrate, wherein the fluid inlet is in fluid communication with the perforations such that fluid that arrives via the fluid inlet will flow through the perforations and continue on through the channels;

a fluid outlet configured to accept fluid that arrives from the outflow end of the channels; and

a housing configured to house the substrate and the array of nanotubes, the housing having a gas inlet configured to route a gas into the spaces between the nanotubes and a gas outlet configured to route the gas away from the spaces between the nanotubes.

20. The apparatus of claim 19, wherein each of the nanotubes is perpendicular to the substrate and wherein each of the channels is perpendicular to the substrate.

21. The apparatus of claim 19, wherein the nanotubes are disposed on the substrate in an array configuration, with a plurality of voids in the array, wherein each of the voids corresponds to a respective channel.

22. An apparatus comprising:

a plurality of units, each of the units including (a) a substrate having a first side and a second side, (b) a plurality of nanotubes disposed on the second side of the substrate with spaces between the nanotubes, wherein the nanotubes are disposed on the substrate in a configuration that leaves a plurality of fluid flow channels that are surrounded by the nanotubes, each of the channels having an inflow end and an outflow end, wherein each of the channels is wide enough for a fluid to flow through, and wherein the nanotubes are spaced close enough to each other to retain the fluid within the channels when the fluid is flowing through the channels, and wherein the substrate has a plurality of perforations that extend between the first side of the substrate and the second side of the substrate, each of the perforations being aligned with a respective one of the channels, (c) a fluid inlet configured to supply fluid to the first side of the substrate, wherein the fluid inlet is in fluid communication with the perforations such that fluid that arrives via the fluid inlet will flow through the perforations and continue on through the channels, and (d) a fluid outlet configured to accept fluid that arrives from the outflow end of the channels;

a housing configured to house the plurality of units, the housing having a gas inlet configured to route a gas into the spaces between the nanotubes, and a gas outlet configured to route the gas away from the spaces between the nanotubes;

a fluid inflow path configured to route incoming fluid to at least one of the units; and

a fluid outflow path configured to route outgoing fluid from at least one of the units.

23. The apparatus of claim 22, wherein the units are interconnected so that the fluid flows through the units in series.

24. The apparatus of claim 23 wherein, in each of the units, each of the nanotubes is perpendicular to the substrate, each of the channels is perpendicular to the substrate, each of the channels has a diameter between 2 and 500 μ

m, and the nanotubes have a diameter between 5 and 20 nm.

25. The apparatus of claim 23 wherein, in each of the units, the nanotubes are disposed on the substrate in an array configuration, with a plurality of voids in the array, with each of the voids corresponding to a respective channel.

26. The apparatus of claim 22, wherein the units are interconnected so that the fluid flows through the units in series.

27. A method for interacting a fluid with a gas, the method comprising the steps of:

providing a plurality of fluid flow channels that are surrounded by nanotubes, each of the channels having an inflow end and an outflow end, wherein each of the channels is wide enough for a fluid to flow through, and wherein the nanotubes are spaced close enough to each other to retain the fluid within the channels when the fluid is flowing through the channels;

passing fluid through the through the channels; and

passing a gas through the spaces between the nanotubes outside the fluid flow channels,

wherein the gas interacts with the fluid in the channels.

28. The method of claim 27, wherein each of the channels has a diameter between 2 and 500 μ

m.

29. The method of claim 27, wherein the nanotubes have a diameter between 5 and 20 nm.

30. The method of claim 27, wherein the nanotubes are spaced on centers that are between 1.5 times the diameter of the nanotubes and 5 times the diameter of the nanotubes.

31. The method of claim 27, wherein the interaction between the gas and the fluid in the channels comprises an exchange of gasses.

32. The method of claim 27, wherein the interaction between the gas and the fluid in the channels comprises an exchange of heat.