METHODS AND COMPOSITIONS FOR INHIBITING CD32B EXPRESSING CELLS
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Abstract
The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell'"'"'s surface and an FcγRIIb on the cell'"'"'s surface, methods for their generation, and methods for using the immunoglobulins.
4 Citations
24 Claims
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1-17. -17. (canceled)
- 18. A protein comprising an Fc variant comprising at least amino acid modifications S267E and L328F as compared to a human Fc polypeptide, wherein numbering is according to the EU index according to Kabat.
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24. A protein comprising at least amino acid modifications S267E and L328F as compared to a human Fc polypeptide, wherein numbering is according to the EU index according to Kabat, wherein said Fc variant has increased binding affinity to Fcγ
- RIIb as compared to the human parent Fc polypeptide.
Specification