METHODS AND DEVICES FOR ENDOVASCULAR EMBOLIZATION

• US 20150039017A1
• Filed: 07/31/2014
• Published: 02/05/2015
• Est. Priority Date: 07/31/2013
• Status: Active Grant

• Current Assignee: Embolic Acceleration, LLC
• Original Assignee: EMBA Medical Limited
• Inventors: Cragg, Andrew H., Logan, John, Naglreiter, Brett E., Espinosa, Alejandro, Arp, Scott R., Green, Nicholas A., Gamez, Victor M.
• Granted Patent: US 9,681,876 B2
• Time in Patent Office: Days
• US Class Current: 606/200
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12168 having a mesh structure A61B17/1214 takes precedence
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12177 comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00778 Operations on blood vessels A61B2017/22097, A61B2017/320741 take precedence
• CPC Class Codes: A61B 2017/00995 having a thin film
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61F 2/01 Filters implantable into blood vessels
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting

Abstract

The present disclosure describes an occlusion device and methods of delivering the occlusion device. The occlusion device can include an expandable structure configured to move between an unexpanded configuration and an expanded configuration. The expandable structure can be configured to have an expansion ratio of at least about 5:1. Further, the occlusion device can be configured to prevent substantially all fluid from flowing past the occlusion device when the occlusion device is in the expanded configuration in the vessel.

Claims

1. A vascular occlusion device, comprising:

a frame comprising a proximal embolic zone and a distal anchoring zone separated by a hub;

the proximal and distal zones self-expandable from a constrained diameter to an unconstrained diameter of at least about 500% of the constrained diameter;

a guidewire lumen through the hub, to permit placement over a guidewire; and

a valve in communication with the guidewire lumen.

2. The endovascular occlusion device as in claim 1, having an expansion ratio of at least about 6:

1.

3. The endovascular occlusion device as in claim 1, having an expansion ratio of at least about 7:

1.

4. The endovascular occlusion device as in claim 1, having an unconstrained expanded diameter of at least about 1.5 mm and which can be deployed from a 0.7 mm or smaller inside diameter lumen.

5. The endovascular occlusion device as in claim 1, having an unconstrained expanded diameter of at least about 6.0 mm and which can be deployed from a 0.7 mm or smaller inside diameter lumen.

6. The endovascular occlusion device as in claim 1, wherein the device is configured to occlude at least about 90 percent of flow through a vessel when the expandable tubular frame is in an expanded configuration.

88. The vascular occlusion device of claim 1, wherein the hub is flexible to allow bending between the proximal and distal zones.

89. The vascular occlusion device of claim 1, wherein the hub is a rigid tube.

90. The vascular occlusion device of claim 1, wherein the hub is partially expandable.

7. An endovascular occlusion device, comprising an expandable occlusive element for expansion within and occlusion of a vessel, the occlusive element having an expansion ratio of at least about 5:

1.

8-47. -47. (canceled)

48. An endovascular occlusion device for mechanical occlusion of blood flow in a vessel, comprising:

a support structure, expandable from a reduced cross section for transluminal navigation to an enlarged cross section for occluding a vessel;

an upstream lobe on the support structure, separated from a downstream lobe by a neck portion;

a guidewire lumen extending through the neck portion;

the upstream lobe comprising a concave configuration which is concave in a direction away from the downstream lobe;

a valve in the guidewire lumen; and

a porous membrane carried by the upstream lobe.

49. An endovascular occlusion device as in claim 48, wherein the downstream lobe comprises a concave configuration, concave in a direction facing away from the upstream lobe.

50. An endovascular occlusion device as in claim 49, wherein the upstream lobe comprises a plurality of side wall struts.

51. An endovascular occlusion device as in claim 50, wherein the side wall struts carry the membrane.

52. An endovascular occlusion device as in claim 48, wherein the valve comprises a collapsible tube extending from the neck portion into the upstream lobe.

53. An endovascular occlusion device as in claim 48, wherein the downstream lobe comprises a plurality of side wall struts.

54. An endovascular occlusion device as in claim 48, wherein following deployment in an artery with the upstream lobe in an anatomically proximal orientation, blood pressure on the concave side of the upstream lobe generates a radially outward force from the upstream lobe against the artery wall.

55. An endovascular occlusion device as in claim 54, wherein blood pressure on the concave side of the upstream lobe generates an axially distal force on the neck portion.

56. The endovascular occlusion device as in claim 48, having an expansion ratio of at least about 6:

1.

57. The endovascular occlusion device as in claim 48, having an expansion ratio of at least about 7:

1.

58. The endovascular occlusion device as in claim 48, having an unconstrained expanded diameter of at least about 6.0 mm and which can be deployed from a 1 mm or smaller inside diameter lumen.

59. The endovascular occlusion device as in claim 48, wherein the device is configured to occlude at least about 90 percent of flow through a vessel when the expandable tubular frame is in an expanded configuration.

60. An endovascular occlusion device as in claim 48, configured to achieve a reduction in blood flow of at least about 80% within 2 minutes of deployment from the tube in a blood vessel.

61. An endovascular occlusion device as in claim 60, configured to achieve a reduction in blood flow of at least about 80% within 1 minute of deployment from the tube in a blood vessel.

62. An endovascular occlusion device as in claim 61, configured to achieve total occlusion within 5 minutes of deployment from the tube in a blood vessel.

63. An endovascular occlusion device as in claim 62, configured to achieve total occlusion within 1 minute of deployment from the tube in a blood vessel.

64. An endovascular occlusion device deployment system, comprising the endovascular occlusion device of claim 51, oriented on an elongate, flexible deployment catheter having a proximal end and a distal end such that the upstream lobe faces the proximal end of the catheter.

65-87. -87. (canceled)