Oil and Liquid Silicone Foamable Carriers and Formulations
11 Assignments
0 Petitions
Accused Products
Abstract
A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
60 Citations
96 Claims
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1-70. -70. (canceled)
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71. An essentially waterless composition in a container, comprising a carrier and a liquefied or compressed gas propellant, wherein the carrier comprises:
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a liquid oil; about 0.5% to about 15% by weight of the carrier of a cyclic silicone; at least one foam stabilizing agent comprising a co surfactant and/or a foam adjuvant or a surfactant comprising a fatty acid ester or a mixture of any two or more thereof; and a minocycline or a doxycycline or both; wherein the ratio of the carrier to the propellant is 100;
3 to 100;
35;wherein the carrier is essentially free of a polyoxyethylene (POE) surfactant; wherein upon release of the composition from the container, a foam results that does not collapse immediately and is breakable on mechanical shear; and
wherein the minocycline or the doxycycline is stable for at least 3 weeks at 25°
C. in the essentially waterless composition. - View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96)
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Specification