Method for Treating Amyloid Disease
1 Assignment
0 Petitions
Accused Products
Abstract
The invention relates to methods for treating human amyloid disease by administration of modified Aβ peptide immunogens.
0 Citations
37 Claims
-
1-23. -23. (canceled)
-
24. A method for treating a patient suffering from an amyloid disease or a tauopathy comprising administering to the patient a therapeutically effective amount of a polymerized form of an immunogenic modified Aβ
- peptide, which peptide contains Lysine substitutions in amino acid positions corresponding to amino acids 18 and 19 of Aβ
1-42, which polymerized form is soluble, non-fibrillogenic, has molecular weight less than 100 kDa, has the property of eliciting antibodies directed against the abnormal conformation of Aβ
in amyloid plaques and/or in soluble and semi-soluble Aβ
oligomers, and is produced using controlled polymerization of peptide monomers with glutaraldehyde. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
- peptide, which peptide contains Lysine substitutions in amino acid positions corresponding to amino acids 18 and 19 of Aβ
Specification