Reversal of General Anesthesia by Administration of Methylphenidate, Amphetamine, Modafinil, Amantadine, and/or Caffeine
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Abstract
The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogues or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general an esthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.
259 Citations
47 Claims
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1-28. -28. (canceled)
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29. A method for determining a state of consciousness of a subject experiencing an administration of at least one anesthetic agent or at least one drug to facilitate emergence from anesthesia, the method comprising:
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acquiring physiological data from the subject through a plurality of electrodes arranged on the subject; applying at least one window to the physiological data; for the at least one window, calculating a multi-taper spectrum estimation; and based on the multi-taper spectrum estimation, generating a spectrogram for the subject. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37)
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38. A method for monitoring a state of consciousness of a subject experiencing an administration of at least one anesthetic agent or at least one drug to facilitate emergence from anesthesia, the method comprising:
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acquiring physiological data from the subject; applying at least one window to the physiological data; for the at least one window, calculating a multi-taper spectrum estimation; and based on the multi-taper spectrum estimation, generating a report providing information about the state of consciousness of the subject. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47)
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Specification