METHODS OF FORMING 4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYLBORONIC ACID PINACOL ESTERS AND METHODS OF USING THE SAME
First Claim
1. A method of forming a 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol ester, comprising:
- contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene;
contacting the lithiated 1-chloro-3-fluoro-2-substituted benzene with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate;
reacting the 4-chloro-2-fluoro-3-substituted-phenylboronate with an aqueous base to form a (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate;
reacting the (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate with an acid to form a 4-chloro-2-fluoro-3-substituted-phenylboronic acid;
reacting the 4-chloro-2-fluoro-3-substituted-phenylboronic acid with 2,3-dimethyl-2,3-butanediol to form a 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol ester; and
subjecting the 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol ester to a Suzuki'"'"'s coupling reaction in a medium consisting essentially of at least one solvent, a Suzuki'"'"'s coupling reactant, a palladium catalyst, a ligand, and a base.
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Abstract
Methods include formation of 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. The method comprises contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene. The lithiated 1-chloro-3-fluoro-2-substituted benzene is contacted with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate. The 4-chloro-2-fluoro-3-substituted-phenylboronate is reacted with an aqueous base to form a (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate. The (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate is reacted with an acid to form a 4 chloro-2-fluoro-3-substituted-phenylboronic acid. The 4-chloro-2-fluoro-3-substituted-phenylboronic acid is reacted with 2,3-dimethyl-2,3-butanediol to form 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters . Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters to produce 6-(4-chloro-2-fluoro-3-substituted-phenyl)-4-aminopicolinates are also disclosed.
4 Citations
15 Claims
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1. A method of forming a 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol ester, comprising:
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contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene; contacting the lithiated 1-chloro-3-fluoro-2-substituted benzene with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate; reacting the 4-chloro-2-fluoro-3-substituted-phenylboronate with an aqueous base to form a (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate; reacting the (4-chloro-2-fluoro-3-substituted-phenyl)trihydroxyborate with an acid to form a 4-chloro-2-fluoro-3-substituted-phenylboronic acid; reacting the 4-chloro-2-fluoro-3-substituted-phenylboronic acid with 2,3-dimethyl-2,3-butanediol to form a 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol ester; and subjecting the 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol ester to a Suzuki'"'"'s coupling reaction in a medium consisting essentially of at least one solvent, a Suzuki'"'"'s coupling reactant, a palladium catalyst, a ligand, and a base. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of forming 2-(4-chloro-2-fluoro-3-methoxylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, comprising:
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contacting 2-chloro-6-fluoroanisole with n-butyl lithium to form 6-chloro-2-fluoro-3-lithioanisole; contacting the 6-chloro-2-fluoro-3-lithioanisole with trimethyl borate to form dimethyl 4-chloro-2-fluoro-3-methoxyphenylboronate; reacting the dimethyl 4-chloro-2-fluoro-3-methoxyphenylboronate with aqueous potassium hydroxide to form potassium (4-chloro-2-fluoro-3-methoxyphenyl)trihydroxyborate; reacting the potassium (4-chloro-2-fluoro-3-methoxyphenyl)trihydroxyborate with aqueous hydrochloric acid to form 4-chloro-2-fluoro-3-methoxyphenylboronic acid; reacting the 4-chloro-2-fluoro-3-methoxyphenylboronic acid with 2,3-dimethyl-2,3-butanediol to form a 2-(4-chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; and subjecting the 2-(4-chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane to a Suzuki'"'"'s coupling reaction in a medium consisting essentially of at least one solvent, a Suzuki'"'"'s coupling reactant, a palladium catalyst, a ligand, and a base. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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Specification