SYSTEM AND METHOD FOR DETERMINING ARTERIAL PULSE WAVE TRANSIT TIME

• US 20150257661A1
• Filed: 03/11/2014
• Published: 09/17/2015
• Est. Priority Date: 03/11/2014
• Status: Abandoned Application

• Current Assignee: Xerox Corporation (Xerox Holdings Corp.)
• Original Assignee: Xerox Corporation (Xerox Holdings Corp.)
• Inventors: MESTHA, Lalit Keshav, KYAL, Survi
• Application Number:
  US14/204,397
• Publication Number:
  US 20150257661A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0015 characterised by features of the telemetry system
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02427 Details of sensor
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light

Abstract

What is disclosed is a system and method for determining the time it takes for an arterial pulse pressure wave to transit between a proximal and a distal point of a patient'"'"'s body. In one embodiment, a signal is received from each of a first and second device worn circumferentially around a proximal and a distal region, respectively. The devices are worn on an area of exposed skin. Each of the devices comprises at least one emitter/detector pair fixed to an inner side of each device and has at least one detector paired to at least one illuminator. Each detector has at least one sensor that is sensitive to a wavelength band of light emitted by its illuminator. Each device generates signals that are proportional to an intensity of light emitted by an illuminator. The signals are analyzed to determine arterial pulse wave transit time between the proximal and distal regions.

Claims

1. A method for determining arterial pulse wave transit time, the method comprising:

receiving a signal from each of a first and second device worn on a proximal and a distal region, respectively, of a subject'"'"'s body, each device comprising at least one emitter/detector pair fixed to an inner side with at least one detector being paired to at least one illuminator, each detector comprising at least one sensor that is sensitive to a wavelength band of light emitted by one of said illuminators, each device generates signals that are proportional to an intensity of light emitted by its illuminator, each emitter/detector pair being separated from its respective paired at least one illuminator by distance D; and

analyzing said signals to determine an arterial pulse wave transit time for said subject between said proximal and distal regions.

2. The method of claim 1, wherein at least one of said devices is a transmissive device, said distance D defining a chord of living tissue through which light emitted by an illuminator passes, said distance being less than 75% of a diametrical distance of an area where said device is worn, each sensor measuring an intensity of light passing through a chord of living tissue.

3. The method of claim 1, wherein at least one of said devices is a reflective device, said distance D defining a distance between each illuminator and paired detector as measured around said circumference, light emitted by an illuminator impacting a surface of skin at an angle θ

_L, each sensor measuring an intensity of light reflecting off said skin surface at an angle θ

_R, where 0°

<

(θ

_L, θ

_R)<

90°

.

4. The method of claim 1, wherein a wavelength band of said illuminators is centered around any of:

660 nm and 940 nm.

5. The method of claim 1, wherein analyzing said signals to determine an arterial pulse wave transit time comprises:

processing signals from each of said devices to generate a time-series signal for each of said proximal and distal regions;

computing, for each of said time-series signals, a phase angle with respect to frequency to obtain a phase v/s frequency curves after phase unwrapping;

extracting, from said phase v/s frequency curves, slopes within a cardiac frequency range of 0.75 to 4.0 Hz; and

computing a difference between said extracted slopes, said difference comprising said arterial pulse wave transit time between said proximal and distal regions.

6. The method of claim 1, wherein analyzing said signals to determine an arterial pulse wave transit time comprises:

analyzing signals from each of said devices to generate a phase difference; and

processing said phase difference with said subject'"'"'s heart rate to determine said arterial pulse wave transit time between said proximal and distal regions.

7. The method of claim 1, further comprising increasing an accuracy of measurements by performing any of:

band pass filtering signals to restrict frequencies of interest;

detrending signals to remove non-stationary components;

averaging signals to obtain a composite signal, discarding signals;

weighting signals based on a statistical analysis; and

discarding intensity values determined to be below a level of acceptability.

8. The method of claim 1, further comprising any of:

activating said illuminators to emit light for a desired length of time;

turning said illuminators ON/OFF according to a pre-defined interval;

turning said bands ON/OFF according to a pre-defined schedule;

changing a wavelength band of any of said illuminators; and

changing a sensitivity of any of said sensors.

9. The method of claim 1, further comprising analyzing said arterial pulse wave transit time to determine any of:

a blood pressure in said subject'"'"'s vascular network;

an amount of blood vessel dilation over time;

a blockage of blood flow;

blood flow velocity; and

an existence of a peripheral vascular disease

10. The method of claim 1, further comprising communicating said arterial pulse wave transit time to a remote device using any of:

a wired and a wireless connection.

11. The method of claim 10, wherein said communication comprises any of:

text, email, picture, graph, chart, and pre-recorded message.

12. A system for determining arterial pulse wave transit time, the system comprising:

a first and second device worn on a proximal and a distal region, respectively, of a subject'"'"'s body, each device comprising at least one emitter/detector pair fixed to an inner side with at least one detector being paired to at least one illuminator, each detector comprising at least one sensor that is sensitive to a wavelength band of light emitted by one of said illuminators, each device communicating signals that are proportional to an intensity of light emitted by its illuminator, each emitter/detector pair being separated from its respective paired at least one illuminator by distance D; and

a processor in communication with said devices, said processor executing machine readable program instructions for analyzing said sensor signals to determine an arterial pulse wave transit time for said subject between said proximal and distal regions.

13. The system of claim 12, wherein at least one of said devices is a transmissive device, said distance D defining a chord of living tissue through which light emitted by an illuminator passes, said distance being less than 75% of a diametrical distance of an area where said device is worn, each sensor measuring an intensity of light passing through a chord of living tissue.

14. The system of claim 12, wherein at least one of said devices is a reflective device, said distance D defining a distance between each illuminator and paired detector as measured around said circumference, light emitted by an illuminator impacting a surface of skin at an angle θ

_L, each sensor measuring an intensity of light reflecting off said skin surface at an angle θ

_R, where 0°

<

(θ

_L, θ

_R)<

90°

.

15. The system of claim 12, wherein a wavelength band of said illuminators is centered around any of:

660 nm and 940 nm.

16. The system of claim 12, wherein analyzing said signals to determine an arterial pulse wave transit time comprises:

processing signals from each of said devices to generate a time-series signal for each of said proximal and distal regions;

computing, for each of said time-series signals, a phase angle with respect to frequency to obtain a phase v/s frequency curves;

extracting, from said phase v/s frequency curves, slopes within a cardiac frequency range of 0.75 to 4.0 Hz; and

computing a difference between said extracted slopes, said difference comprising said arterial pulse wave transit time between said proximal and distal regions.

17. The system of claim 12, wherein analyzing said signals to determine an arterial pulse wave transit time comprises:

analyzing signals from each of said devices to generate a phase difference; and

processing said phase difference with said subject'"'"'s heart rate to determine said arterial pulse wave transit time between said proximal and distal regions.

18. The system of claim 12, said processor further increasing an accuracy of measurements by performing any of:

band pass filtering signals to restrict frequencies of interest;

detrending signals to remove non-stationary components;

averaging signals to obtain a composite signal, discarding signals;

weighting signals based on a statistical analysis; and

discarding intensity values determined to be below a level of acceptability.

19. The system of claim 12, said processor further performing any of:

activating said illuminators to emit light for a desired length of time;

turning said illuminators ON/OFF according to a pre-defined interval;

turning said bands ON/OFF according to a pre-defined schedule;

changing a wavelength band of any of said illuminators; and

changing a sensitivity of any of said sensors.

20. The system of claim 12, further comprising analyzing said arterial pulse wave transit time to determine any of:

a blood pressure in said subject'"'"'s vascular network;

an amount of blood vessel dilation over time;

a blockage of blood flow;

blood flow velocity; and

an existence of a peripheral vascular disease.

21. The system of claim 12, wherein at least one of said devices further comprises a connection for receiving power from a power source.

22. The system of claim 12, said processor communicating said arterial pulse wave transit time to a remote device using any of:

a wired and a wireless connection.

23. The system of claim 22, wherein, in response to said determination, said remote device communicating any of:

text, email, picture, graph, chart, and pre-recorded message.

24. The system of claim 22, wherein said remote device is any of:

a smartphone, an iPad, a tablet-PC, a laptop, a router, a server, and a computer workstation.

25. The system of claim 24, wherein said remote device further comprises any of:

a USB connection, a micro-HDMI connection, a transmitter, a receiver, a display, a memory, a storage device, and a connection for delivering power to said apparatus.