PROCESS FOR THE PREPARATION OF A FLUOROLACTON DERIVATIVE
First Claim
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1. A process for the preparation of a fluorolactone derivative of the formula
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Abstract
A novel process for the preparation of a fluorolactone derivative of the formula
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- and of its acylated derivative of formula
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- wherein R1 stands for a hydroxy protecting group is described.
The acylated fluorolactones of formula V, particularly the benzoyl derivative with R1=benzyl are important precursors for the synthesis of prodrug compounds which have the potential to be potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.
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Citations
23 Claims
- 1. A process for the preparation of a fluorolactone derivative of the formula
- 17. A fluoropropionate derivative of formula
- 20. An aldol adduct of the formula
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