Analysis of Bioparticles in an Optical Microcavity
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Abstract
This invention provides new methods and apparatus for rapidly analyzing a single bioparticle or a plurality of bioparticles to assess their condition. The invention is enabled by an optical microcavity comprising reflective structures to confine light and bioparticles in the same space. Under resonance conditions, an electromagnetic standing wave is established in the microcavity to interact with the bioparticle. Means are provided to bring a bioparticle into the microcavity and to detect changes in the resonance condition with and without the bioparticle in the microcavity. Information about the bioparticle is obtained using the benefits of light interactions as fast, non-contacting, and non-destructive.
5 Citations
39 Claims
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1-17. -17. (canceled)
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18. An apparatus for multiple beam Interference microscopy comprising:
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an optical cavity with highly reflective structures arranged to confine light within a space; a light source to provide light inside said cavity; an optical resonance condition and a standing wave in the cavity arising from multiple beam interference; a means to bring a bioparticle into the cavity, and an optical detector to measure changes in said resonance condition with and without said bioparticle in the cavity, whereby biomolecular information about a bioparticle can be obtained and transformed to an output display using the benefits of light interactions as fast, non-contacting, and non-destructive. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method for bioparticle analysis in an optical cavity comprising the steps of:
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using said optical cavity with highly reflective structures arranged to confine light within a space containing a gain region; operating the optical cavity in a lasing mode to establish an optical resonance condition with a standing wave in the cavity; bringing said bioparticle into the optical cavity with said resonance condition; detecting light emitted from the cavity with the bioparticle; and measuring fluctuations in said light emitted from the cavity induced by the bioparticle, whereby information about a bioparticle is obtained and transformed to an output display. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38)
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39-56. -56. (canceled)
Specification