TAMPER RESISTANT DOSAGE FORMS
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
5 Citations
199 Claims
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1-169. -169. (canceled)
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170. A method of treating pain comprising administering to a patient in need thereof a pharmaceutical tablet comprising:
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(1) at least a first compression shaped and air cured matrix comprising an opioid or a pharmaceutically acceptable salt thereof in combination with at least one high molecular weight polyethylene oxide having, based on rheological measurements, an approximate molecular weight selected from 4,000,000 and 7,000,000 and optionally further comprising at least one low molecular weight polyethylene oxide having, based on rheological measurements, an approximate molecular weight of less than 1,000,000; (2) optionally a second air cured matrix comprising an opioid or a pharmaceutically acceptable salt thereof in combination with at least one low molecular weight polyethylene oxide having, based on rheological measurements, an approximate molecular weight of less than 1,000,000; and (3) optionally a coating, wherein said high molecular weight polyethylene oxide is at least 50% by weight of the total weight of said uncoated tablet; the total combined weight of said high and low molecular weight polyethylene oxide is at least 60% by weight of the total weight of said uncoated tablet; and said tablet provides a once-daily or twice-daily extended release tablet of said opioid or pharmaceutically acceptable salt thereof. - View Dependent Claims (171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199)
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Specification