EVALUATION, ASSAYS AND TREATMENT OF PKAL-MEDIATED DISORDERS

  • US 20150362492A1
  • Filed: 01/17/2014
  • Published: 12/17/2015
  • Est. Priority Date: 01/20/2013
  • Status: Active Grant
First Claim
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1. A method, comprising:

  • contacting a sample containing plasma protease C1 inhibitor (C1-INH) with a capture reagent, andmeasuring a level of the C1-INH in the sample that binds to the capture reagent;

    wherein the capture reagent comprises;

    i) an active form of Factor XII, or a C1-INH-binding fragment thereof,ii) an active form of plasma kallikrein, or a C1-INH-binding fragment thereof, oriii) a combination of i) and ii).

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