SYSTEMS FOR TREATING POST-TRAUMATIC STRESS DISORDER

• US 20150374994A1
• Filed: 09/10/2015
• Published: 12/31/2015
• Est. Priority Date: 03/11/2013
• Status: Active Grant

• Current Assignee: Ohio State Innovation Foundation (Ohio State University)
• Original Assignee: Ohio State Innovation Foundation (Ohio State University)
• Inventors: Rezai, Ali R., Nelson, Randy J., Weil, Zachary M.
• Granted Patent: US 10,065,037 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36062 Spinal stimulation
• CPC Class Codes: A61N 1/36096 Mood disorders, e.g. depression, anxiety or panic disorder
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue

Abstract

One aspect of the present disclosure relates to a closed-loop therapy system for treating post-traumatic stress disorder (PTSD) in a subject. The therapy delivery system can include a sensing component, a delivery component, and a controller. The sensing component can be configured to detect at least one physiological parameter associated with PTSD. The delivery component can be configured for implementation on or about a ganglion of the sympathetic nervous system (SNS). The controller can be configured to automatically coordinate operation of the sensing and delivery components. The controller can also be configured to deliver an electrical signal to the delivery component so that activity of the ganglion of the SNS is substantially blocked without enhancing a symptom of PTSD.

Claims

1-19. -19. (canceled)

20. A closed-loop therapy delivery system for treating post-traumatic stress disorder (PTSD) in a subject, the therapy delivery system comprising:

a sensing component configured to detect at least one physiological parameter associated with PTSD;

a delivery component configured for implantation on or about a ganglion of the sympathetic nervous system (SNS); and

a controller configured to automatically coordinate operation of the sensing and delivery components;

wherein the controller is programmed to deliver an electrical signal to the delivery component so that activity of the ganglion of the SNS is substantially blocked to treat the PTSD without enhancing a symptom of PTSD.

21. The system of claim 20, wherein the controller is programmed to deliver an electrical signal that continuously blocks at least some of the activity of the ganglion of the SNS.

22. The system of claim 20, wherein the electrical signal has a frequency range of about 10,000 Hz to about 25,000 Hz.

23. The system of claim 20, wherein all or only a portion of the system is implanted within the subject.

24. The system of claim 20, wherein the at least one physiological parameter includes a chemical moiety or an electrical activity.

25. The system of claim 20, wherein the ganglion of the SNS is a cervical ganglion, a cervicothoracic ganglion, or a thoracic ganglion.

26. The system of claim 25, wherein the cervical ganglion is an upper, middle, or lower cervical ganglion.

27. The system of claim 20, wherein the controller is programmed to deliver an electrical signal to the delivery component without increasing the temperature of the ganglion of the SNS.

28. The system of claim 20, wherein the controller is programmed to deliver magnetic energy to the ganglion of the SNS.

37. The method of claim 20, wherein the therapy delivery device is configured to deliver magnetic energy to the ganglion of the SNS.

29. A method for treating PTSD in a subject, the method comprising the steps of:

placing a therapy delivery device into electrical communication with a ganglion of the SNS associated with PTSD; and

activating the therapy delivery device to deliver an electrical signal to the ganglion of the SNS so that activity of the ganglion of the SNS is substantially blocked to treat the PTSD without enhancing a symptom of PTSD.

30. The method of claim 29, further comprising the steps of:

sensing at least one physiological parameter associated with PTSD;

generating a sensor signal based on the at least one physiological parameter; and

activating the therapy delivery device to adjust application of the electrical signal to the ganglion of the SNS in response to the sensor signal to treat PTSD.

31. The method of claim 29, wherein delivering an electrical signal to the ganglion of the SNS continuously blocks at least some of the activity of the ganglion of the SNS.

32. The method of claim 29, wherein the electrical signal has a frequency range of about 10,000 Hz to about 25,000 Hz.

33. The method of claim 30, wherein the at least one physiological parameter includes a chemical moiety or an electrical activity.

34. The method of claim 29, wherein the ganglion of the SNS is a cervical ganglion, a cervicothoracic ganglion, or a thoracic ganglion.

35. The method of claim 34, wherein the cervical ganglion is an upper, middle, or lower cervical ganglion.

36. The method of claim 29, wherein the electrical signal is delivered to the ganglion of the SNS without increasing the temperature of the ganglion.

38. A method for treating PTSD in a subject, the method comprising the steps of:

implanting a therapy delivery device within the subject;

placing the therapy delivery device into electrical communication with the stellate ganglion; and

activating the therapy delivery device to deliver an electrical signal to the stellate ganglion so that activity of the ganglion of the SNS is substantially blocked to treat the PTSD without enhancing a symptom of PTSD.

39. The method of claim 38, wherein the electrical signal has a frequency range of about 10,000 Hz to about 25,000 Hz.