LIQUID MEASUREMENT SYSTEMS, APPARATUS, AND METHODS OPTIMIZED WITH TEMPERATURE SENSING

• US 20160030673A1
• Filed: 08/03/2015
• Published: 02/04/2016
• Est. Priority Date: 08/01/2014
• Status: Active Grant

• Current Assignee: Bigfoot Biomedical, Inc.
• Original Assignee: Common Sensing, Inc.
• Inventors: White, James, Whalley, Richard, Sihlanick, Kevin, Legrand, Matthew
• Granted Patent: US 10,255,991 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3379 Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/8212 with means or measures taken for minimising energy consumption
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: G01F 22/00 Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for
• CPC Class Codes: G01F 23/0015 with a whistle or other sonorous signal
• CPC Class Codes: G01F 23/2921 for discrete levels
• CPC Class Codes: G01F 23/2961 : for discrete levels G01F23/2962 - G01F23/2968 take precedence
• CPC Class Codes: G01K 13/02 : for measuring temperature of moving fluids or granular materials capable of flow
• CPC Class Codes: G01K 13/026 : of moving liquids
• CPC Class Codes: G16H 10/60 : for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 20/17 : delivered via infusion or injection

Abstract

An apparatus for measuring liquid volume in a container includes a plurality of light sources for emitting electromagnetic radiation (EMR) toward the container, a plurality of sensors optically coupleable to the plurality of light sources, each sensor of the plurality of sensors for detecting the EMR emitted by at least a portion of the plurality of light sources, a temperature sensor for measuring at least one temperature associated with a liquid in the container, and at least one processor for receiving data representative of the portion of the detected EMR from each of the plurality of sensors, comparing the at least one measured temperature to a temperature guideline to identify any temperature events associated with the received data; normalizing the received data based on any temperature events associated with the received data; and converting the normalized data into a signature representative of the EMR detected by the plurality of sensors.

Claims

1. An apparatus for measuring liquid volume in a container, the apparatus comprising:

a plurality of light sources disposed and configured to emit electromagnetic radiation toward the container;

a plurality of sensors optically coupleable to the plurality of light sources, each sensor of the plurality of sensors disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the plurality of light sources;

a temperature sensor disposed and configured to measure at least one temperature associated with a liquid in the container; and

at least one processor configured to receive data representative of the portion of the detected electromagnetic radiation from each of the plurality of sensors and the at least one measured temperature from the temperature sensor, the processor operable to;

compare the at least one measured temperature to a temperature guideline to identify any temperature events associated with the received data;

normalize the received data based on any temperature events associated with the received data; and

convert the normalized data into a signature representative of the electromagnetic radiation detected by the plurality of sensors.

2. The apparatus of claim 1, wherein the temperature guideline includes at least one of a baseline temperature, a maximum temperature, and a minimum temperature.

3. The apparatus of claim 2, wherein the temperature guideline further includes at least one of an amount of one-time exposure above the maximum temperature and the minimum temperature, an amount of one-time exposure below the minimum temperature, an amount of cumulative exposure above the maximum temperature, an amount of cumulative exposure below the minimum temperature, a maximum rate of temperature change, and a maximum frequency of temperature fluctuations.

4. The apparatus of claim 1, wherein the temperature guideline is specific to at least one of the apparatus, the container, and the liquid.

5. The apparatus of claim 1, wherein a temperature event is at least one of a relationship and a difference between the at least one measured temperature and the at least one temperature guideline.

6. The apparatus of claim 1, further comprising a memory configured to store at least one of:

the at least one measured temperature; and

the temperature guideline.

7. The apparatus of claim 1, wherein the at least one processor is further configured to determine at least one of a level of efficacy, a level of safety, a level of subject comfort, and an expiration status associated with the liquid based on any temperature events associated with the received data.

8. The apparatus of claim 7, further comprising at least one communication interface configured to communicate information associated with the at least one of the level of efficacy, the level of safety, the level of subject comfort, and the expiration status associated with the liquid to a user.

9. The apparatus of claim 1, further comprising a glucometer configured to measure blood glucose of a subject, wherein the at least one processor is further configured to:

receive a blood glucose measurement; and

normalize the blood glucose measurement based on any temperature events associated with the blood glucose measurement.

10. A method of estimating a volume of liquid in a drug container, the method comprising:

causing a plurality of light sources to emit electromagnetic radiation toward the drug container;

detecting the emitted electromagnetic radiation through the drug container with a plurality of sensors;

measuring at least one temperature associated with the liquid in the drug container with a temperature sensor;

comparing the at least one measured temperature to a temperature guideline to identify any temperature events associated with the detected electromagnetic radiation;

normalizing data representative of the portion of the detected electromagnetic radiation from each of the plurality of sensors based on any temperature events associated with the detected electromagnetic radiation;

converting the normalized data into a signature representative of the electromagnetic radiation detected by the plurality of sensors; and

comparing the signature to a plurality of reference signatures to determine the volume of liquid in the drug container.

11. The method of claim 10, wherein the temperature guideline includes at least one of a baseline temperature, a maximum temperature, and a minimum temperature.

12. The method of claim 11, wherein the temperature guideline further includes at least one of an amount of one-time exposure above the maximum temperature and the minimum temperature, an amount of one-time exposure below the minimum temperature, an amount of cumulative exposure above the maximum temperature, an amount of cumulative exposure below the minimum temperature, a maximum rate of temperature change, and a maximum frequency of temperature fluctuations.

13. The method of claim 10, wherein the temperature guideline is specific to at least one of the apparatus, the container, and the liquid

14. The method of claim 10, wherein a temperature event is at least one of a relationship and a difference between the at least one measured temperature and the at least one temperature guideline.

15. The method of claim 10, further comprising storing at least one of:

the at least one measured temperature; and

the temperature guideline.

16. The method of claim 10, further comprising determining at least one of a level of efficacy, a level of safety, a level of subject comfort, and an expiration status associated with the liquid based on any temperature events associated with the received data.

17. The method of claim 16, further comprising communicating information associated with the at least one of the level of efficacy, the level of safety, the level of subject comfort, and the expiration status associated with the liquid to a user.

18. The method of claim 10, further comprising:

measuring a blood glucose level of a subject; and

normalizing the blood glucose measurement based on any temperature events associated with the blood glucose measurement.

19. A method, comprising:

causing a plurality of light sources to emit electromagnetic radiation toward an injection pen a first time;

detecting the emitted electromagnetic radiation through the injection pen with a plurality of sensors;

measuring at least one temperature associated with a liquid in the injection pen with a temperature sensor;

comparing the at least one measured temperature to a temperature guideline to identify any temperature events associated with the detected electromagnetic radiation;

normalizing data representative of the portion of the detected electromagnetic radiation from each of the plurality of sensors based on any temperature events associated with the detected electromagnetic radiation;

converting the normalized data into a first signature representative of the electromagnetic radiation detected by the plurality of sensors;

comparing the first signature to a plurality of reference signatures to determine a first volume of liquid in the injection pen;

repeating the steps of causing the plurality of light sources to emit electromagnetic radiation, detecting the emitted electromagnetic radiation, measuring at least one temperature associated with a liquid in the injection pen, comparing the at least one measured temperature to a temperature guideline to identify any temperature events associated with the detected electromagnetic radiation, normalizing data representative of the portion of the detected electromagnetic radiation from each of the plurality of sensors based on any temperature events; and

converting the normalized data into a second signature, and comparing the second signature to the plurality of reference signatures to determine a second volume of liquid in the injection pen; and

estimating a dose delivered from the injection pen based on the first volume and the second volume.

20. A health management system, comprising:

a drug delivery device including a drug reservoir; and

a dose measurement system configured to be removably coupleable to the drug delivery device, the dose measurement system including;

a plurality of light sources disposed and configured to emit electromagnetic radiation toward the drug reservoir;

a temperature sensor disposed and configured to measure at least one temperature associated with a liquid in the drug delivery device;

a plurality of sensors optically coupleable to the plurality of light sources, each sensor of the plurality of sensors disposed and configured to detect a quantity of electromagnetic radiation communicated through the drug reservoir;

at least one processor configured to receive data representative of the portion of the detected electromagnetic radiation from each of the plurality of sensors and the at least one measured temperature from the temperature sensor, the processor operable to;

compare the at least one measured temperature to a temperature guideline to identify any temperature events associated with the received data;

normalize the received data based on any temperature events associated with the received data; and

convert the normalized data into a signature representative of the volume of liquid remaining in the drug reservoir; and

a display configured to present information to a user indicative of the volume of liquid remaining in the drug reservoir.