USE OF A DPP-4 INHIBITOR IN PODOCYTES RELATED DISORDERS AND/OR NEPHROTIC SYNDROME

• US 20160082011A1
• Filed: 10/30/2015
• Published: 03/24/2016
• Est. Priority Date: 05/14/2012
• Status: Active Grant

• Current Assignee: Boehringer Ingelheim International GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Boehringer Ingelheim International GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Inventors: KLEIN, Thomas, von EYNATTEN, Maximilian, HOCHER, Berthold, MARK, Michael, SHARKOVSKA, Yuliya
• Granted Patent: US 9,526,730 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/18 Sulfonamides compounds containing a para-N-benzene-sulfonyl-N- group A61K31/63
• CPC Class Codes: A61K 31/401 Proline; Derivatives thereof, e.g. captopril
• CPC Class Codes: A61K 31/4184 condensed with carbocyclic rings, e.g. benzimidazoles
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 1/18 for pancreatic disorders, e.g. pancreatic enzymes
• CPC Class Codes: A61P 13/00 Drugs for disorders of the urinary system
• CPC Class Codes: A61P 13/02 of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 27/12 for cataracts
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 : Antihyperlipidemics
• CPC Class Codes: A61P 3/08 : for glucose homeostasis pancreatic hormones A61P5/48
• CPC Class Codes: A61P 3/10 : for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/10 : Antioedematous agents; Diuretics
• CPC Class Codes: A61P 9/00 : Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/04 : Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 : Antihypertensives
• CPC Class Codes: C07D 473/06 : with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Abstract

The present invention relates to methods for treating and/or preventing podocytes related disorders and/or nephrotic syndrome comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and/or preventing a metabolic disease in a patient with or at risk of podocytes related disorders and/or nephrotic syndrome.

Claims

1. A method for treating nephrotic syndrome, wherein the nephrotic syndrome is minimal change disease (MCD), membranous nephropathy (MN) and/or focal segmental glomerulosclerosis (FSGS);

or caused by or associated with minimal change disease (MCD), membranous nephropathy (MN) and/or focal segmental glomerulosclerosis (FSGS), the method comprising administering linagliptin to a patient in need thereof, optionally in combination with one or more other active agents.

2. The method according to claim 1, wherein the nephrotic syndrome is primary or secondary.

3. The method according to claim 1, wherein the nephrotic syndrome is resistant or refractory to conventional therapy.

4. The method according to claim 1, wherein the DPP-4 inhibitor is linagliptin, optionally in combination with one or more other active agents, and the method is for treating nephrotic syndrome caused by or associated with minimal change disease (MCD), membranous nephropathy (MN) and/or focal segmental glomerulosclerosis (FSGS).

5. The method according to claim 1, wherein the DPP-4 inhibitor is linagliptin, optionally in combination with one or more other active agents, and the method is for treating nephrotic syndrome caused by, or associated with minimal change disease (MCD) which is minimal change nephropathy.

6. The method according to claim 1, wherein the DPP-4 inhibitor is linagliptin, optionally in combination with one or more other active agents, and the method is treating nephrotic syndrome caused by, or associated with membranous nephropathy (MN).

7. The method according to claim 1, wherein the DPP-4 inhibitor is linagliptin, optionally in combination with one or more other active agents, and the method is for treating nephrotic syndrome caused by, or associated with focal segmental glomerulosclerosis (FSGS).

8. The method according to claim 1, wherein the patient has type 1 diabetes, type 2 diabetes, or LADA.

9. The method according to claim 1, wherein the patient has type 2 diabetes mellitus.

10. The method according to claim 1, wherein the patient is non-diabetic.

11. The method according to claim 1, wherein the patient is impaired in renal function and/or has nephropathy and/or albuminuria.

12. The method according to claim 4, wherein the one or more other active agents include active substances which are indicated in the treatment of nephrotic syndrome are selected from the group consisting of corticosteroids, diuretics, angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), cyclophosphamide, cyclosporine, and/or anticoagulants.

13. The method according to claim 1, wherein the nephrotic syndrome is manifested by proteinuria, edema, hypoalbuminemia, hyperlipidemia and, optionally, hypertension.