MICROFABRICATED DEVICE WITH MICRO-ENVIRONMENT SENSORS FOR ASSAYING COAGULATION IN FLUID SAMPLES
First Claim
1. A sample analysis cartridge comprising:
- an inlet chamber configured to receive a biological sample; and
a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber, the conduit comprising;
a micro-environment prothrombin time (PT) sensor; and
a micro-environment activated partial thromboplastin time (aPTT) sensor.
1 Assignment
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Accused Products
Abstract
The present invention relates to sample analysis cartridges comprising micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using micro-environment sensors in a point of care sample analysis cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample, and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber. The conduit may include a micro-environment prothrombin time (PT) sensor, and a micro-environment activated partial thromboplastin time (aPTT) sensor.
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Citations
24 Claims
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1. A sample analysis cartridge comprising:
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an inlet chamber configured to receive a biological sample; and a conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber, the conduit comprising; a micro-environment prothrombin time (PT) sensor; and a micro-environment activated partial thromboplastin time (aPTT) sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A sample analysis cartridge comprising:
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an inlet chamber configured to receive a biological sample; a first conduit fluidically connected to the inlet chamber and configured to receive the biological sample from the inlet chamber, the first conduit comprising a junction configured to split the biological sample into at least first and second segments; a second conduit fluidically connected to the first conduit at the junction and configured to receive the first segment of the biological sample, the second conduit comprising a prothrombin time (PT) reagent and a PT sensor, and a third conduit fluidically connected to the first conduit at the junction and configured to receive the second segment of the biological sample, the third conduit comprising an activated partial thromboplastin time (aPTT) reagent and an aPTT sensor, wherein one of the second and third conduits comprises a flow restrictor positioned upstream of the PT sensor or the aPTT sensor. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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21. A sample analysis cartridge comprising:
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a conduit comprising a micro-environment coagulation sensor and a blood chemistry sensor; and a pump configured to move a biological sample within the conduit to contact the micro-environment coagulation sensor and the blood chemistry sensor at substantially a same time.
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22. A sample analysis cartridge comprising:
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a conduit comprising at least one coagulation sensor, a pH sensor, a partial pressure CO2 sensor, a partial pressure O2 sensor, and a lactate sensor; and a pump configured to move a biological sample within the conduit to contact each of the at least one coagulation sensor, the pH sensor, the partial pressure CO2 sensor, the partial pressure O2 sensor, and the lactate sensor.
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23. A chip comprising:
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a micro-environment prothrombin time (PT) sensor; a micro-environment activated partial thromboplastin time (aPTT) sensor; and a counter reference electrode.
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24. A chip comprising:
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a micro-environment prothrombin time (PT) sensor; a micro-environment activated clotting time (ACT) sensor, and a counter reference electrode.
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Specification