METHODS OF TREATING ANAEMIA
First Claim
Patent Images
1. A method of treating or reducing the risk of anaemia in a human haemodialysis patient, the method comprising administering an anti-BMP6 trap, antibody or antibody fragment to the human haemodialysis patient,wherein the trap, antibody or antibody fragment comprises a constant region selected from:
- (a) a human gamma-4 heavy chain constant region that comprises a Leu at position 189 shown in SEQ ID NO;
73 or an Arg at position 289 shown in SEQ ID NO;
73; and
(b) a human gamma-1 heavy chain constant region that comprises an Asp corresponding to position 204 of SEQ ID NO;
42 or a Leu corresponding to position 206 of SEQ ID NO;
42; and
wherein the human comprises(i) a TMPRSS6 nucleotide sequence comprising a SNP rs855791;
rs2543519;
rs2235324;
or rs1421312; and
(ii) a constant region gene segment encoding said selected constant region;
or said patient expresses antibodies comprising said selected constant region.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
3 Citations
30 Claims
-
1. A method of treating or reducing the risk of anaemia in a human haemodialysis patient, the method comprising administering an anti-BMP6 trap, antibody or antibody fragment to the human haemodialysis patient,
wherein the trap, antibody or antibody fragment comprises a constant region selected from: -
(a) a human gamma-4 heavy chain constant region that comprises a Leu at position 189 shown in SEQ ID NO;
73 or an Arg at position 289 shown in SEQ ID NO;
73; and(b) a human gamma-1 heavy chain constant region that comprises an Asp corresponding to position 204 of SEQ ID NO;
42 or a Leu corresponding to position 206 of SEQ ID NO;
42; andwherein the human comprises (i) a TMPRSS6 nucleotide sequence comprising a SNP rs855791;
rs2543519;
rs2235324;
or rs1421312; and(ii) a constant region gene segment encoding said selected constant region;
or said patient expresses antibodies comprising said selected constant region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
-
-
17. A method of treating anaemia in a human haemodialysis patient in need thereof, the improvement comprising:
-
administering to said patient an anti-BMP6 trap, antibody or antibody fragment to specifically bind in the patient a BMP6; wherein the trap, antibody, or antibody fragment comprises a constant region selected from; a. a human gamma-4 heavy chain constant region that comprises a Leu at position 189 shown in SEQ ID NO;
73 or an Arg at position 289 shown in SEQ ID NO;
73, orb. a human gamma-1 heavy chain constant region that comprises an Asp corresponding to position 204 of SEQ ID NO;
42 or a Leu corresponding to position 206 of SEQ ID NO;
42; andwherein said patient comprises; (i) TMPRSS6 nucleotide sequence comprising a SNP rs855791;
rs2543519;
rs2235324;
or rs1421312; and(ii) a constant region gene segment encoding said selected constant region;
orwherein said patient expresses antibodies comprising said selected constant region. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
-
Specification