HUMAN ANTIBODIES BINDING TO RSV G PROTEINS
First Claim
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1. An antibody able to specifically bind to the G protein of a respiratory syncytial virus (RSV) and able to neutralize RSV A and B strains, wherein the antibody binds to an epitope within the central conserved domain of the RSV G protein, wherein said epitope comprises amino acids 160-169 and amino acids 184-192 of the RSV G protein RSV A2 strain or corresponding amino acids in a strain other than RSV A2.
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Abstract
The disclosure provides isolated antibodies and antigen-binding fragments that bind to the G protein of RSV and which are capable of neutralizing RSV.
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20 Claims
- 1. An antibody able to specifically bind to the G protein of a respiratory syncytial virus (RSV) and able to neutralize RSV A and B strains, wherein the antibody binds to an epitope within the central conserved domain of the RSV G protein, wherein said epitope comprises amino acids 160-169 and amino acids 184-192 of the RSV G protein RSV A2 strain or corresponding amino acids in a strain other than RSV A2.
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5. An antigen-binding fragment that specifically binds to the G protein of a respiratory syncytial virus (RSV) and neutralizes RSV A and B strains, wherein the antigen-biding fragment binds to an epitope comprising
amino acids 160-169 of the RSV G protein RSV A2 strain or corresponding amino acids in a strain other than RSV A2, and amino acids 184-192 of the RSV G protein RSV A2 strain or corresponding amino acids in a strain other than RSV A2.
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6. A functional variant of an antibody that specifically binds to the G protein of a respiratory syncytial virus (RSV) and neutralizes RSV A and B strains, wherein the antibody binds to an epitope comprising:
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amino acids 160-169 of the RSV G protein RSV A2 strain or corresponding amino acids in a strain other than RSV A2, and amino acids 184-192 of the RSV G protein RSV A2 strain or corresponding amino acids in a strain other than RSV A2. - View Dependent Claims (13, 18, 20)
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Specification