PROSTHETIC MITRAL VALVE

• US 20160158013A1
• Filed: 10/12/2015
• Published: 06/09/2016
• Est. Priority Date: 01/23/2004
• Status: Active Grant

• Current Assignee: Edwards Lifesciences Corporation
• Original Assignee: Edwards Lifesciences Corporation
• Inventors: Carpentier, Alain F., Lam, Hung L., Lafrance, Hugues
• Granted Patent: US 9,730,794 B2
• Time in Patent Office: Days
• CPC Class Codes: A61F 2/2403 with pivoting rigid closure members check valves with hinged closure members in general F16K15/03
• CPC Class Codes: A61F 2/2409 Support rings therefor, e.g. for connecting valves to tissue annuloplasty rings A61F2/2442
• CPC Class Codes: A61F 2/2412 with soft flexible valve members, e.g. tissue valves shaped like natural valves check valves with flexible valve members in general F16K15/14
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2448 D-shaped rings
• CPC Class Codes: A61F 2230/0008 elliptical or oval
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61F 2230/0095 Saddle-shaped

Abstract

A prosthetic mitral valve with a compressible and expandable stent that, when expanded, is circumferentially oval, elliptical, or D-shaped, with a major axis and a minor axis ratio of from about 3:4 to about 4:5. Embodiments of the stent comprise three commissure posts disposed towards an outflow end and three curved cusp regions between adjacent commissure posts. Three flexible leaflets are attached to the commissure posts in a tri-foil configuration. Embodiments of the prosthetic mitral valve include an atrial ring disposed at the inflow end of the stent.

Claims

1. A prosthetic mitral valve comprising:

an inflow end, an outflow end, and a central flow axis extending from the inflow end to the outflow end;

a cloth-covered ring disposed at the inflow end of the prosthetic mitral valve, the ring configured for positioning on an atrial side of a native mitral valve annulus and for holding the prosthetic mitral valve in place;

a compressible and expandable stent extending from the ring towards the outflow end of the prosthetic mitral valve, the stent comprising biocompatible metal, the stent, when expanded, being circumferentially D-shaped with a major axis longer than a minor axis thereof, with a ratio of the minor axis to the major axis from about 3;

4 to about 4;

5, the stent dimensioned for placement within the native mitral valve annulus, the stent having an approximately conical shape with a smaller diameter towards the outflow end of the prosthetic mitral valve, the stent including three commissure posts angling slightly inwardly, tips of the commissure posts at a smaller diameter end of the stent; and

a cloth cover disposed over the stent.

2. A prosthetic mitral valve comprising:

an inflow end, an outflow end, and a central flow axis extending from the inflow end to the outflow end;

a ring disposed at the inflow end of the prosthetic mitral valve, the ring configured for positioning on an atrial side of a native mitral valve annulus; and

a compressible and expandable stent extending from the ring towards the outflow end of the prosthetic mitral valve, the stent comprising biocompatible metal, the stent, when expanded, being circumferentially oval, elliptical, or D-shaped with a major axis longer than a minor axis thereof, the stent dimensioned for placement within the native mitral valve annulus, the stent having an approximately conical shape with a smaller diameter towards the outflow end of the prosthetic mitral valve.

3. The prosthetic mitral valve of claim 2, wherein the ring is oval, elliptical, or D-shaped.

4. The prosthetic mitral valve of claim 2, wherein the ring further comprises a cover comprising cloth, biocompatible fabric, or polyester terephthalate.

5. The prosthetic mitral valve of claim 2, wherein the stent is circumferentially D-shaped.

6. The prosthetic mitral valve of claim 2, wherein a ratio of the minor axis to the major axis of the stent is from about 3:

4 to about 4;

5.

7. The prosthetic mitral valve of claim 2, wherein the commissure posts comprise first and second commissure posts disposed substantially symmetrically about the minor axis, and a third commissure post disposed substantially on the minor axis.

8. The prosthetic mitral valve of claim 2, wherein the stent comprises three commissure posts.

9. The prosthetic mitral valve of claim 2, wherein the stent comprises commissure post angled radially inwards towards the flow axis.

10. The prosthetic mitral valve of claim 2, further comprising a cover disposed over the stent.

11. The prosthetic mitral valve of claim 10, wherein the cover comprises at least one of cloth, biocompatible fabric, and polyester terephthalate.