NASAL DRUG PRODUCTS AND METHODS OF THEIR USE

  • US 20160184294A1
  • Filed: 11/24/2015
  • Published: 06/30/2016
  • Est. Priority Date: 03/14/2014
  • Status: Active Grant
First Claim
Patent Images

1. A method of treatment of opioid overdose or a symptom thereof,comprising nasally administering to a patient in need thereof a dose of naloxone hydrochloride using a single-use, pre-primed device adapted for nasal delivery of a pharmaceutical composition to a patient by one actuation of said device into one nostril of said patient, having a single reservoir comprising a pharmaceutical composition which is an aqueous solution of about 100 μ

  • L comprising;

    about 4 mg naloxone hydrochloride or a hydrate thereof;

    between about 0.2 mg and about 1.2 mg of an isotonicity agent;

    between about 0.005 mg and about 0.015 mg of a compound which is at least one of a preservative, a cationic surfactant, and a permeation enhancer;

    between about 0.1 mg and about 0.5 mg of a stabilizing agent; and

    an amount of an acid sufficient to achieve a pH of 3.5-5.5.

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