PEPTIDE CONJUGATES OF GLP-1 RECEPTOR AGONISTS AND GASTRIN AND THEIR USE
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Abstract
The present invention relates, inter alia, to certain peptide conjugates, and to the use of the conjugates in the treatment of a variety of diseases or disorders, including diabetes (type 1 and/or type 2) and diabetes-related diseases or disorders.
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Citations
54 Claims
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1-3. -3. (canceled)
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4. A peptide conjugate or pharmaceutically acceptable salt thereof having the formula
R1—- Z-L-Y—
R2
(I)wherein R1 is H, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl; R2 is OH or NH2; Za is a peptide sequence having the formula III - View Dependent Claims (11, 12, 13, 14, 30, 31, 32, 36, 37, 38, 39, 40, 41, 42, 45, 46, 48, 49, 50, 51, 52, 53, 54)
- Z-L-Y—
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5-10. -10. (canceled)
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15-29. -29. (canceled)
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33-35. -35. (canceled)
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43-44. -44. (canceled)
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47. (canceled)
Specification