NERVE STIMULATION AND BLOCKING FOR TREATMENT OF GASTROINTESTINAL DISORDERS

• US 20160193465A1
• Filed: 11/02/2015
• Published: 07/07/2016
• Est. Priority Date: 02/03/2003
• Status: Active Grant

• Current Assignee: ReShape LifeSciences, Inc.
• Original Assignee: EnteroMedics, Inc. (ReShape LifeSciences, Inc.)
• Inventors: Knudson, Mark B., Wilson, Richard R., Tweden, Katherine S., Conrad, Timothy R.
• Granted Patent: US 9,682,233 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/321 Electromedical belts
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/3606 adapted for a particular treatment
• CPC Class Codes: A61N 1/36071 Pain

Abstract

At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.

Claims

1-6. -6. (canceled)

7. A method for treating at least one of a plurality of disorders of a gastrointestinal tract of a patient where the disorders are characterized at least in part by hyper-tonal vagal activity the method comprises applying at least one electrode adapted to be placed on a vagus nerve below a vagal innervation of the heart;

delivering an electrical signal to the vagus nerve having a frequency of at least 500 Hz and having at least one parameter selected to i) at least partially downregulate efferent or afferent nerve activity of the vagus nerve, and ii) allow at least partial recovery of the nerve activity following discontinuation of the electrical signal.

8. The method of claim 7, further comprising parameters selected to reduce pancreobilliary output.

9. The method of claim 7, wherein the electrical signal delivered is only a downregulating signal.

10. The method of claim 7, wherein the timing of the electrical signal is intermittent.

11. The method of claim 7, wherein the at least one electrode is adapted to be placed on a vagal trunk.

12. The method of claim 11, wherein the vagal trunk innervates an organ selected from the group consisting of an esophagus, stomach, pancreas, duodenum, jejunum, and ileum.

13. The method of claim 7, wherein the at least one parameter for the electrical signal is selected from the group consisting of frequency, amplitude, pulse width, timing and duty cycle.

14. The method of claim 13, wherein the selected parameter is timing of the electrical signal.

15. The method of claim 14, wherein the electrical signal is applied once every ten minutes.

16. The method of claim 7, wherein the vagus nerve comprises an anterior, a posterior, or anterior and posterior vagus nerves.