CONTAINER CLOSURE SYSTEM

• US 20160213566A1
• Filed: 08/05/2015
• Published: 07/28/2016
• Est. Priority Date: 01/26/2015
• Status: Active Grant

• Current Assignee: Fresenius KABI Deutschland GmbH (Else Kröner-Fresenius-Stiftung)
• Original Assignee: Fresenius KABI Deutschland GmbH (Else Kröner-Fresenius-Stiftung)
• Inventors: JBSTL, Elisabeth, WEGNER, Gerald, SOLBERG-ERIKSEN, Asbjrn, DELAPORTE, Eric
• Granted Patent: US 10,201,475 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61J 1/10 Bag-type containers
• CPC Class Codes: A61J 1/1468 Containers characterised by specific material properties
• CPC Class Codes: A61J 1/16 Holders for containers
• CPC Class Codes: B65D 2203/02 Labels
• CPC Class Codes: B65D 2203/06 Arrangements on packages concerning bar-codes
• CPC Class Codes: B65D 25/205 Means for the attachment of labels, cards, coupons or the like; cards or coupons for the other types of rigid or semi-rigid containers B65D25/36 takes precedence
• CPC Class Codes: B65D 31/02 with laminated walls
• CPC Class Codes: B65D 33/004 Information or decoration elements, e.g. level indicators, detachable tabs or coupons
• CPC Class Codes: B65D 77/04 Articles or materials enclosed in two or more containers disposed one within another

Abstract

The invention relates to a pharmaceutical product or container closure system containing an overpouch with an intransparent first foil and a transparent second foil, a transparent primary container for holding a transparent liquid, e.g., a pharmaceutical formulation, wherein the transparent primary container is packed within the overpouch and labeled with at least one label and wherein the at least one label acts as a light absorbing segment having a reflection R_L for light in the range of about 350 nm to about 800 nm and an inner surface of the intransparent first foil of the overpouch acts as a light reflecting background having a reflection R_F for light in the direction of the primary container in the range of about 350 nm to about 800 nm with R_F≢R_L. By the transparent second foil and the inventive reflection properties it is achieved that the at least one label on the primary container is visible and readable. Additionally, visual inspection of the content of the transparent primary container is possible. A good contrast is achieved to enhance machine and human readability.

Claims

1. A pharmaceutical product comprising

an overpouch with an intransparent first foil and a transparent second foil,

a transparent primary container containing a pharmaceutical formulation,

wherein the transparent primary container is packed within the overpouch and labeled with at least one label and

wherein the at least one label has a reflection R_L for light in the range of 350 nm to 800 nm and an inner surface of the intransparent first foil of the overpouch has a reflection R_F for light in the direction of the primary container in the range of 350 nm to 800 nm, and wherein R_L≢

R_F.

2. The pharmaceutical product according to claim 1, wherein the at least one label acts as light absorbing segment and the overpouch acts as a light reflecting background, and wherein R_F>

R_L.

3. The pharmaceutical product according to claim 1, wherein the at least one label acts as light reflecting segment and the overpouch acts as a light absorbing background, and wherein R_L>

R_F.

4. The pharmaceutical product according to claim 1, wherein

the label is a dark color, and the inner surface of the intransparent first foil of the overpouch is a light color, or

the label is a light color, and the inner surface of the intransparent first foil of the overpouch is a dark color.

5. The pharmaceutical product according to claim 1, wherein

the label is imprinted on the outer side of the transparent primary container facing the transparent second foil of the overpouch, and

that the inner surface of the intransparent first foil of the overpouch comprises a colored polymeric layer.

6. The pharmaceutical product according to claim 1, wherein the label contains text information, a barcode, a symbol, a drawing, or a combination thereof related to the content of the primary container.

7. The pharmaceutical product according to claim 1, wherein 0.5×

R_F≧

R_L and R_F≧

0.5.

8. The pharmaceutical product according to claim 7, comprising a symbol contrast (SC) wherein SC−

|R_F−

R_L|≧

0.5.

9. The pharmaceutical product according to claim 7, wherein R_F≧

0.9, and R_L≦

0.1.

10. The pharmaceutical product according to claim 1, wherein 0.5×

R_L≧

R_F and R_L≧

0.5.

11. The pharmaceutical product according to claim 10, comprising a symbol contrast (SC) wherein SC−

|R_F−

R_L|≧

0.5.

12. The pharmaceutical product according to claim 10, wherein R_L≧

0.9, and R_F≦

0.1.

13. The pharmaceutical product according to claim 1, wherein the intransparent first foil of the overpouch is a multilayer-foil having an outer layer and an inner layer providing the inner surface.

14. The pharmaceutical product according to claim 13, comprising

a metallic layer located between the outer layer and the inner layer.

15. The pharmaceutical product according to claim 14, wherein

the outer layer is a polyester layer or a polypropylene layer, the inner layer is an intransparent polypropylene layer, and the metallic layer is an aluminum layer.

16. The pharmaceutical product according to claim 15, wherein the polyester layer comprises polyethylene terephthalate or the polypropylene layer comprises an oriented polypropylene layer.

17. The pharmaceutical product according to claim 15, wherein the polyester layer, the polypropylene layer and the metallic layer have a thickness between 5 μ

m and 50 μ

m and the intransparent polypropylene layer has a thickness between 50 μ

m and 150 μ

m.

18. The pharmaceutical product according to claim 1, wherein the transparent second foil of the overpouch is a multilayer foil having an outer layer and an inner layer.

19. The pharmaceutical product according to claim 18, comprising

an inorganic oxide layer located between the outer layer and the inner layer.

20. The pharmaceutical product according to claim 19, wherein the inorganic oxide layer comprises an oxide of aluminum or silicon.

21. The pharmaceutical product according to claim 18, wherein the outer layer is a first polyester layer and the inner layer is a polypropylene layer.

22. The pharmaceutical product according to claim 21, wherein the polyester layer is sealed on the outside of the overpouch with a heat sealable coating.

23. The pharmaceutical product according to claim 21, wherein the polyester layer has a thickness between 5 μ

m and 50 μ

m and the polypropylene layer has a thickness between 50 μ

m and 150 μ

m.

24. The pharmaceutical product according to claim 21, comprising a second polyester layer having a thickness between 5 μ

m and 50 μ

m located between the first polyester layer and the polypropylene layer.

25. The pharmaceutical product according to claim 24, wherein the first polyester layer and the second polyester layer comprise polyethylene terephthalate.

26. The pharmaceutical product according to claim 1, further comprising an oxygen absorber or an oxygen indicator.

27. The pharmaceutical product according to claim 1, wherein the intransparent first foil is deepdrawable.

28. A container closure system comprising

an overpouch with an intransparent first foil and a transparent second foil,

a transparent primary container for holding a liquid,

wherein the transparent primary container is packed within the overpouch and labeled with at least one label and

wherein the at least one label has a reflection R_L for light in the range of about 350 nm to about 800 nm and an inner surface of the intransparent first foil of the overpouch has a reflection R_F for light in the direction of the primary container in the range of 350 nm to 800 nm, and wherein R_L≢

R_F.

29. The container closure system according to claim 28, wherein the at least one label acts as light absorbing segment and the overpouch acts as a light reflecting background, and wherein R_F>

R_L.

30. The container closure system according to claim 28, wherein the at least one label acts as light reflecting segment and the overpouch acts as a light absorbing background, and wherein R_L>

R_F.

31. A pharmaceutical product comprising

an overpouch with an intransparent first foil and a transparent second foil,

a transparent primary container containing a pharmaceutical formulation,

wherein the transparent primary container is packed within the overpouch and labeled with at least one label and

wherein the at least one label has a reflection R_L for light and an inner surface of the intransparent first foil of the overpouch has a reflection R_F for light in the direction of the primary container, and wherein the at least one label can be read by a machine or by a human.