METHODS AND SENSORS FOR DETECTING A BIOLOGICAL PARAMETER
First Claim
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31. A method of determining the ovulation status of a subject, the method comprising:
- implanting into the subject a sensor comprising one or more porous silicon layers and a luteinizing hormone binding molecule, wherein the sensor comprise an optical reflectance property between 400 and 1200 nm which is responsive to binding of leutinizing hormone to the sensor;
detecting an optical reflectance property between 400 and 1200 nm through the skin from the implanted sensor; and
determining the ovulation status of the subject on the basis of the optical reflectance property detected.
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Abstract
The present disclosure relates to methods for detecting a biological parameter and to sensors for detecting a biological parameter. Certain embodiments of the present disclosure provide a method of detecting a biological parameter in a subject, the method comprising: implanting a sensor into the subject, wherein the sensor comprises an optical reflectance property between 400 and 1200 nm which is responsive to the biological parameter; detecting an optical reflectance property between 400 and 1200 nm through the skin of the subject from the implanted sensor, and using the optical reflectance property to detect the biological parameter.
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60 Claims
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31. A method of determining the ovulation status of a subject, the method comprising:
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implanting into the subject a sensor comprising one or more porous silicon layers and a luteinizing hormone binding molecule, wherein the sensor comprise an optical reflectance property between 400 and 1200 nm which is responsive to binding of leutinizing hormone to the sensor; detecting an optical reflectance property between 400 and 1200 nm through the skin from the implanted sensor; and determining the ovulation status of the subject on the basis of the optical reflectance property detected.
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32. A method of determining the pregnancy status of a subject, the method comprising:
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implanting into the skin a sensor comprising one or more porous silicon layers and a molecule that binds to an analyte indicative of pregnancy status, wherein the sensor comprise an optical reflectance property between 400 and 1200 nm which is responsive to binding of the analyte to the sensor; detecting an optical reflectance property between 400 and 1200 nm through the skin from the implanted sensor; and determining the pregnancy status of the subject on the basis of the optical reflectance property detected.
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- 33. A sensor for detecting a biological parameter, the sensor comprising one or more porous silicon layers, wherein the sensor comprises an optical reflectance property between 400 and 1200 nm that is responsive to the biological parameter.
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34-1. The sensor according to claim 33 or 35, wherein the sensor comprises an optical reflectance property between 550 and 750 nm.
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