CRITERIA FOR DETERMINATION OF LOCAL TISSUE LATENCY NEAR PACING LEAD ELECTRODES

• US 20160213928A1
• Filed: 01/22/2016
• Published: 07/28/2016
• Est. Priority Date: 01/23/2015
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Ghosh, Subham
• Granted Patent: US 9,750,941 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/282 Holders for multiple electrodes for introduction into the body A61B5/287
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A system and method for identifying whether local tissue latency is present. The system and method comprises an implanted lead having a first electrode for cardiac pacing and sensing. A sensing module for sensing heart activity with the first electrode to produce an electrogram (EGM) waveform. A processor is configured to receive the EGM waveform and extract two or more features from the EGM waveform representative of heart activity in response to monoventricular or biventricular pacing stimulus at the electrode and identify local tissue latency at a site of the first electrode based upon at least two of the extracted features indicating local tissue latency.

Claims

1. An apparatus for adjusting one or more control pacing parameters for cardiac pacing, comprising:

(a) delivering means for delivering a left ventricular pacing stimulus at a short atrioventricular (AV) delay equal to or less than 60 ms;

(b) sensing means for sensing a signal in response to the ventricular pacing stimulus;

(c) processing means for determining from the signal a minimum time (Tmin) associated with a minimum amplitude;

(d) processing means for determining whether Tmin≧

100 milliseconds (ms); and

(e) processing means for determining whether to adjust one or more control pacing parameters, in response to determining whether Tmin≧

100 ms, wherein the control pacing parameters being one of AV delay, inter-ventricular (VV) delay, pacing vector, and pacing output.

2. The apparatus of claim 1 further comprising:

processing means for determining local tissue latency exists in response to determining that the Tmin≧

100 ms.

3. The apparatus of claim 1 wherein the AV delay is shortened in response to determining that the Tmin≧

100 ms.

4. The apparatus of claim 2 wherein the AV delay is shortened to be less than or equal to 80 ms.

5. The apparatus of claim 2 wherein the AV delay is shortened to be less than or equal to 60 ms.

8. The apparatus of claim 1, wherein acquiring the signal comprises selecting a sensing vector comprising a left ventricular electrode and a right ventricular coil electrode.

9. The apparatus of claim 1, further comprising:

delivering means for delivering a biventricular pacing at the short AV delay.

10. The apparatus of claim 1, further comprising:

processing means for adjusting the VV delay so that the left ventricular pacing stimulus is delivered ahead of the right ventricular pacing stimulus.

11. The apparatus of claim 1, wherein the left ventricular pacing stimulus is delivered ahead of the right ventricular pacing stimulus in about 5 ms or more, 10 ms or more, 15 ms or more, 20 ms or more, 25 ms or more, 30 ms or more, 35 ms or more, and 40 ms or more.

6. The apparatus of claim 6 wherein the AV delay is adjusted by a pre-specified level.

7. The apparatus of claim 6 wherein the AV delay decreased by a prespecified level being one of 5 ms, 10 ms, 15 ms, 20 ms, 25 ms, 30 ms, 35 ms, and 50 ms.

12. An apparatus for adjusting one or more control pacing parameters for cardiac resynchronization, comprising:

(a) delivering means for delivering biventricular pacing stimulus comprising a right ventricular pacing stimulus and a left ventricular pacing stimulus simultaneously at a short atrioventricular (AV) delay equal to or less than 60 ms;

(b) sensing means for sensing a signal in response to the biventricular pacing stimulus;

(c) processing means for determining from the signal a maximum amplitude (Max), a maximum time (Tmax) associated with the Max, a maximum amplitude (Min), and a minimum time (Tmin) associated with the Min, a minimum amplitude, determined within pre-specified time period following the delivery of the biventricular pacing;

(d) processing means for determining whether Tmin>

Tmax associated with the signal; and

(e) processing means for determining whether to adjust VV delay in response to determining Tmin>

Tmax.

13. The apparatus of claim 12 further comprising:

processing means for determining local tissue latency exists in response to determining that Tmin>

Tmax.

14. The apparatus of claim 12 further comprising:

processing means for adjusting the VV delay so that the LV stimulus is delivered 10 ms ahead of the RV stimulus.

15. The apparatus of claim 12 further comprising:

processing means for adjusting the VV delay so that the LV stimulus is delivered 20 ms ahead of the RV stimulus.

16. The apparatus of claim 12 further comprising:

processing means for adjusting the VV delay so that the LV stimulus is delivered 40 ms ahead of the RV stimulus.

17. The apparatus of claim 12, wherein acquiring the signal comprises selecting a sensing vector comprising a left ventricular electrode and a right ventricular coil electrode.

18. A medical device system for determining presence of local tissue latency, the system comprising:

an implanted lead having a first electrode for cardiac pacing and sensing;

a sensing module for producing a waveform;

a processor configured to;

(a) setting one or more pacing control parameters including setting an atrioventricular (AV) delay to less than or equal to 60 ms,

(b) extracting two or more features from the waveform,

(c) identifying whether local tissue latency is at a site of the first electrode based upon at least two of the extracted features indicating local tissue latency, and

(d) in response to identifying local tissue latency, adjusting the one or more pacing control parameters.

19. An apparatus for adjusting pacing parameters for cardiac resynchronization, comprising

a) delivering a left ventricular pacing stimulus at a short AV delay equal to or less than 60 ms;

b) sensing a signal in response to the left ventricular stimulus and determining if the time-interval between the timing (Tmin) of the minimum amplitude and the time of delivery of the stimulus is 100 ms or greater, where the minimum amplitude is determined within a pre-specified time-period following the delivery of the pacing stimulus;

c) delivering a right ventricular pacing stimulus and a left ventricular pacing stimulus simultaneously at a short AV delay equal to or less than 60 ms;

d) sensing a signal in response to the biventricular pacing stimulus and determining if timing (Tmax) of max amplitude precedes timing (Tmin) of the minimum amplitude where both maximum and minimum amplitudes are determined within a pre-specified time-period following delivery of the pacing stimuli; and

e) adjusting pacing parameters in response to determining if Tmin for the left ventricular stimulus is 100 ms or greater than 100 ms, or if Tmax precedes Tmin for the biventricular pacing stimulus.

20. A non-transitory, computer-readable storage medium comprising instructions that, when executed, cause a processor included in a medical device system to:

(a) deliver a left ventricular pacing stimulus at a short atrioventricular (AV) delay equal to or less than 60 ms;

(b) sense a signal in response to the ventricular pacing stimulus;

(c) determine from the signal a minimum time (Tmin) associated with the minimum amplitude;

(d) determine whether Tmin≧

100 milliseconds (ms); and

(e) determine whether to adjust control pacing parameters, in response to determining whether Tmin≧

100 ms, wherein the control pacing parameters being one of AV delay, inter-ventricular (VV) delay, pacing vector, and pacing output.

21. A medical device system for determining presence of local tissue latency, the system comprising:

an implanted lead having a first electrode for cardiac pacing and sensing;

a sensing module for sensing heart activity with the first electrode to produce a electrogram (EGM) waveform; and

a processor configured to acquire or access the EGM waveform and extract two or more features from the EGM waveform representative of heart activity at the electrode and identify local tissue latency at a site of the first electrode based upon at least two of the extracted features indicating local tissue latency.

22. The system of claim 21 wherein the two or more features from the EGM waveform comprise minimum amplitude, minimum time (Tmin) associated with the minimum amplitude, the processor further configured to determine whether Tmin≧

100 milliseconds.

23. The system of claim 21, wherein the processor further configured to adjust a pacing control parameter in response to determining Tmin≧

100 milliseconds.

24. The system of claim 21, wherein the processor further configured to deliver pacing at a short atrioventricular (AV) delay equal to or less than 60 ms.

25. The system of claim 21 wherein the two or more features from the EGM waveform comprise minimum amplitude, minimum time (Tmin) associated with the minimum amplitude, maximum amplitude, maximum time (Tmax) associated with the maximum amplitude, the processor further configured to determine whether Tmin>

Tmax.

26. The system of claim 25, wherein the processor further configured to adjust a pacing control parameter in response to determining Tmin>

Tmax.

(e) processing means for determining whether to adjust one or more control pacing parameters in response to determining whether local tissue latency, wherein the control pacing parameters being one of AV delay, inter-ventricular (VV) delay, pacing vector, and pacing output.

27. The system of claim 26 further comprising:

processing means for determining local tissue latency exists in response to determining that the Tmin≧

100 ms.

28. The system of claim 26 wherein the AV delay is shortened in response to determining that the Tmin≧

100 ms.

29. The system of claim 28 wherein the AV delay is shortened to be less than or equal to 80 ms.

30. The system of claim 28 wherein the AV delay is shortened to be less than or equal to 60 ms.

31. The system of claim 28 wherein the AV delay is adjusted by a pre-specified level.

32. The system of claim 31 wherein the AV delay decreased by a prespecified level being one of 5 ms, 10 ms, 15 ms, 20 ms, 25 ms, 30 ms, 35 ms, and 50 ms.

33. The system of claim 26, further comprising:

delivering means for delivering a biventricular pacing at the short AV delay.

34. The system of claim 26, further comprising:

in response to identifying local latency tissue, processing means for adjusting the VV delay so that the left ventricular pacing stimulus is delivered ahead of the right ventricular pacing stimulus.

35. The system of claim 26, wherein the left ventricular pacing stimulus is delivered ahead of the right ventricular pacing stimulus in about 5 ms or more, 10 ms or more, 15 ms or more, 20 ms or more, 25 ms or more, 30 ms or more, 35 ms or more, and 40 ms or more.