Nucleic Acid Of Coded GPC3 Chimeric Antigen Receptor Protein And T Lymphocyte Expressing GPC3 Chimeric Antigen Receptor Protein

  • US 20160215261A1
  • Filed: 05/06/2014
  • Published: 07/28/2016
  • Est. Priority Date: 05/08/2013
  • Status: Active Grant
First Claim
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1. A nucleic acid encoding a chimeric antigen receptor targeting GPC3 for expressing at the surface of human T lymphocyte, said chimeric antigen receptor targeting GPC3 comprises, connected in the order of, an extracellular binding domain, a transmembrane region, and an intracellular signaling domain, wherein the extracellular binding domain comprises a single chain antibody scFv(GPC3) which specifically recognizes C-terminal epitope of GPC3.

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