FORMULATIONS and PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2

  • US 20160235733A1
  • Filed: 02/16/2016
  • Published: 08/18/2016
  • Est. Priority Date: 09/18/2012
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition comprising, in a solid dosage form for oral delivery of between about 100 mg and about 1 g total weight:

  • between about 2% and about 18% of d6-tetrabenazine;

    between about 60% and about 70% mannitol;

    between about 15% and about 25% microcrystalline cellulose;

    between about 1% and about 10% of a polyvinylpyrrolidone;

    between about 0.5% and about 2% of a polysorbate;

    between about 5% and about 20% of a poly(ethylene oxide) polymer; and

    between about 0.5% and about 2% of magnesium stearate.

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