METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION
First Claim
1. A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula:
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Abstract
A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof:
comprises: (a) reacting Compound (X):
or a pharmaceutically acceptable salt thereof with Compound (Y):
in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z):
or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
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Citations
68 Claims
- 1. A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula:
- 44. A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula:
- 54. A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula:
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62. A method of preparing Compound (2) or a pharmaceutically acceptable salt thereof, wherein Compound (2) is represented by the following structural formula:
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63. A method of preparing Compound (C) or pharmaceutically acceptable salt thereof, comprising:
(g) reacting Compound (A) - View Dependent Claims (64, 65)
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66. A method of preparing Compound (N), comprising:
(q) reacting Compound (K) - View Dependent Claims (67, 68)
Specification