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PHARMACEUTICAL COMPOSITIONS COMPRISING AZD9291

  • US 20160324854A1
  • Filed: 01/02/2015
  • Published: 11/10/2016
  • Est. Priority Date: 01/02/2014
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition comprising:

  • (a) from 2 to 70 parts of the Agent;

    (b) from 5 to 96 parts of two or more pharmaceutical diluents;

    (c) from 0 to 15 parts of one or more pharmaceutical disintegrants;

    (d) from 0 to 1.5 parts of one or more pharmaceutical solubilising agents; and

    (e) from 0 to 3 parts of one or more pharmaceutical lubricants;

    wherein all parts are by weight and the sum of the parts (a)+(b)+(c)+(d)+(e)=100;

    wherein one of the two or more pharmaceutical diluents is microcrystalline cellulose wherein the microcrystalline cellulose makes up from 7 to 30 wt % of the two or more pharmaceutical diluents (b); and

    wherein the Agent is N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3 -yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide or a pharmaceutically acceptable salt thereof.

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