Method For Using Nanodiamonds To Detect Nearby Magnetic Nanoparticles
First Claim
1. A method comprising:
- exposing a portion of vasculature in a human body to illumination, wherein the human body includes an in vivo imaging agent, wherein the in vivo imaging agent comprises functionalized nanodiamonds and functionalized magnetic nanoparticles, wherein each of the functionalized nanodiamonds contains at least one color center and is functionalized to selectively interact with an analyte in the portion of vasculature, wherein each of the magnetic nanoparticles is functionalized to selectively interact with the analyte in the portion of vasculature, and wherein the illumination causes individual color centers to emit light having one or more properties relating to proximity between the individual color centers and the functionalized magnetic nanoparticles; and
detecting the one or more properties of the light emitted by the color centers in response to the illumination.
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Accused Products
Abstract
An imaging agent for detecting analytes in an environment includes functionalized nanodiamonds and functionalized magnetic particles that can selectively interact with an analyte. Each functionalized nanodiamond contains at least one color center configured emit light in response to illumination. At least one property of the light emitted by the color centers is related to the proximity of the functionalized magnetic particles to the color centers. This property can be detected to determine that the functionalized nanodiamonds are proximate to the functionalized magnetic particles, to determine that the functionalized nanodiamonds and the functionalized magnetic particles are interacting with the analyte, or other applications. Devices and methods for detecting properties of the analyte by interacting with the functionalized nanodiamonds and functionalized magnetic particles are also provided.
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20 Claims
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1. A method comprising:
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exposing a portion of vasculature in a human body to illumination, wherein the human body includes an in vivo imaging agent, wherein the in vivo imaging agent comprises functionalized nanodiamonds and functionalized magnetic nanoparticles, wherein each of the functionalized nanodiamonds contains at least one color center and is functionalized to selectively interact with an analyte in the portion of vasculature, wherein each of the magnetic nanoparticles is functionalized to selectively interact with the analyte in the portion of vasculature, and wherein the illumination causes individual color centers to emit light having one or more properties relating to proximity between the individual color centers and the functionalized magnetic nanoparticles; and detecting the one or more properties of the light emitted by the color centers in response to the illumination. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A device comprising:
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a light source, wherein light emitted from the light source illuminates a portion of vasculature, wherein the portion of vasculature includes an in vivo imaging agent, wherein the in vivo imaging agent comprises functionalized nanodiamonds and functionalized magnetic nanoparticles, wherein each of the functionalized nanodiamonds contains at least one color center and is functionalized to selectively interact with an analyte in the portion of vasculature, wherein each of the magnetic nanoparticles is functionalized to selectively interact with the analyte in the portion of vasculature, and wherein the illumination causes individual color centers to emit light having one or more properties relating to proximity between the individual color centers and the functionalized magnetic nanoparticles; and a light sensor, wherein the light sensor receives light emitted from the portion of vasculature, wherein the light sensor detects one or more properties of light emitted by the color centers in response to the illumination. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification