Microfluidic Device For Multiplexed Point Source Administration Of Compounds

• US 20160346524A1
• Filed: 06/01/2015
• Published: 12/01/2016
• Est. Priority Date: 06/01/2015
• Status: Active Grant

• Current Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: Burkard, Mark E., Wilke, Lee G., Beebe, David J., Warrick, Jay W., Guckenberger, David J.
• Granted Patent: US 9,867,974 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027

Abstract

A device is provided for the administration of a compound in a body. The device includes a capsule having a reservoir therein for receiving the compound therein and a delivery instrument for positioning the capsule within the body. The delivery instrument includes a barrel having an interior adapted to receive the capsule therein and a dispersal element interacting with the barrel to selectively expel the capsule therefrom and into the body. A diffusion regulator communicates with the reservoir and controls the diffusion of the compound from the reservoir into the body. A retention structure projects from capsule and is configured to retain the capsule at a desired location within the body. Multiple devices may be used in conjunction to provide a multiplexed point source to administer multiple compounds simultaneously in vivo.

Claims

1. A device for the administration of a compound in a body, comprising:

a capsule having an inner surface defining a reservoir for receiving the compound therein; and

a diffusion regulator communicating with the reservoir, the diffusion regulator controlling the diffusion of the compound from the reservoir into the body.

2. The device of claim 1 wherein the capsule has opposite first and second ends and wherein the device further comprises a seal engageable with the first end of the capsule, the seal configured for preventing the compound from exiting the reservoir through the first end of the capsule.

3. The device of claim 1 wherein the diffusion regulator includes a needle having a first end communicating with the reservoir and a second end receivable in the body.

4. The device of claim 1 further comprising a retention structure projecting from capsule, the retention structure configured to retain the capsule at a desired location within the body.

5. The device of claim 4 wherein the capsule has opposite first and second ends and wherein the retention structure includes at least one barb projecting from the second end of the capsule, the at least one barb engageable with the body.

6. The device of claim 1 further comprising a delivery instrument configured for positioning the capsule within the body, the delivery instrument including:

an elongated tube having an inner surface defining a passage for receiving the capsule therein, and first and second ends; and

a push rod slideably received in the first end of the elongated tube, the push rod engageable with the capsule for urging the capsule from the passage of the elongated tube through the second end thereof.

7. The device of claim 6 wherein the second end of the elongated tube is beveled to facilitate the insertion of the elongated tube into the body.

8. The device of claim 1 further comprising a delivery instrument configured for positioning the capsule within the body, the delivery instrument including:

a barrel having an interior adapted to receive the capsule therein; and

a dispersal element configured to expel the capsule from the barrel and into the body.

9. A device for the administration of a compound in a body, comprising:

a capsule having a reservoir therein for receiving the compound therein;

a delivery instrument configured for positioning the capsule within the body, the delivery instrument including;

a barrel having an interior adapted to receive the capsule therein; and

a dispersal element interacting with the capsule to selectively expel the capsule from the barrel and into the body;

a diffusion regulator communicating with the reservoir, the diffusion regulator controlling the diffusion of the compound from the reservoir into the body; and

a retention structure projecting from the capsule, the retention structure configured to retain the capsule at a desired location within the body.

10. The device of claim 9 wherein the capsule has opposite first and second ends and wherein the device further comprises a seal engageable with the first end of the capsule, the seal configured to prevent the compound from exiting the reservoir through the first end of the capsule.

11. The device of claim 9 wherein the diffusion regulator includes a needle having a first end communicating with the reservoir and a second end receivable in the body.

12. The device of claim 9 wherein the retention structure includes at least one barb projecting from the capsule, the at least one barb is movable from a first retracted position to a second extended position in response to the capsule being expelled from the barrel.

13. The device of claim 9 wherein the barrel is defined by an elongated tube having an inner surface defining a passage for receiving the capsule therein, and first and second ends.

14. The device of claim 13 wherein the dispersal element includes a push rod slideably received in the first end of the elongated tube, the push rod engageable with the capsule for selectively urging the capsule from the passage of the elongated tube through the second end thereof.

15. The device of claim 13 wherein the second end of the elongated tube is beveled to facilitate the insertion of the elongated tube into the body.

16. A device for the administration of a compound in a body, comprising:

a capsule having a reservoir therein for receiving the compound therein;

a diffusion regulator communicating with the reservoir, the diffusion regulator controlling the diffusion of the compound from the reservoir into the body; and

a retention structure projecting from capsule, the retention structure configured to retain the capsule at a desired location within the body.

17. The device of claim 16 further comprising an injection structure for injecting the capsule into the body.

18. The device of claim 17 wherein the retention structure includes at least one barb projecting from the capsule, the at least one barb is movable from a first retracted position to a second extended position in response to injection of the capsule into the body.

19. The device of claim 17 wherein the injection structure includes an elongated tube having an inner surface defining a passage for receiving the capsule therein, and first and second ends.

20. The device of claim 19 wherein the injection structure includes a push rod slideably received in the first end of the elongated tube, the push rod engageable with the capsule for selectively urging the capsule from the passage of the elongated tube into the body through the second end thereof.

21. The device of claim 19 wherein the second end of the elongated tube is beveled to facilitate the insertion of the elongated tube into the body.

22. The device of claim 16 wherein the capsule has opposite first and second ends and wherein the device further comprises a seal engageable with the first end of the capsule, the seal configured to prevent the compound from exiting the reservoir through the first end of the capsule.

23. The device of claim 16 wherein the diffusion regulator includes a needle having a first end communicating with the reservoir and a second end receivable in the body.