ANTIVIRAL COMPOUNDS AND USES THEREOF
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Abstract
This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
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51 Claims
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1-25. -25. (canceled)
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26. A compound or salt thereof, wherein:
the compound corresponds in structure to formula (I-L0); - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 47, 48, 49, 50, 51)
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46. A compound or salt thereof, wherein the compound is selected from the group consisting of
N-(6-(3-tert-butyl-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-methoxyphenyl)naphthalen-2-yl)methanesulfonamide; -
N-(6-(3-tert-butyl-2-methoxy-5-ureidophenyl)naphthalen-2-yl)methanesulfonamide; N-(6-(3-tert-butyl-2-methoxy-5-(3-phenylureido)phenyl) naphthalen-2-yl)methanesulfonamide; N-(6-(3-tert-butyl-5-(3-isopropylureido)-2-methoxyphenyl) naphthalen-2-yl)methanesulfonamide; tert-butyl 2-(3-tert-butyl-4-methoxy-5-(6-(methylsulfonamido) naphthalen-2-yl)phenylamino)-2-oxoethylcarbamate; 2-amino-N-(3-tert-butyl-4-methoxy-5-(6-(methylsulfonamido) naphthalen-2-yl)phenyl)acetamide; ethyl 3-(3-(3-tert-butyl-4-methoxy-5-(6-(methylsulfonamido) naphthalen-2-yl)phenyl)ureido)propanoate; N-(6-(3-tert-butyl-5-(3-ethylureido)-2-methoxyphenyl) naphthalen-2-yl)methanesulfonamide; tert-butyl 3-(3-tert-butyl-4-methoxy-5-(6-(methylsulfonamido) naphthalen-2-yl)phenylamino)-3-oxopropylcarbamate; 3-amino-N-(3-tert-butyl-4-methoxy-5-(6-(methylsulfonamido) naphthalen-2-yl)phenyl)propanamide; N-(6-(5-benzoyl-3-tert-butyl-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide; (E)-N-(4-(5-benzoyl-3-tert-butyl-2-methoxystyryl)phenyl) methanesulfonamide; (E)-N′
-((3′
-tert-butyl-5′
-(2-(1,1-dioxidoisothiazolidin-2-yl))-2′
methoxybiphenyl-4-yl)methylene)methanesulfonylhydrazide;N-(3-tert-butyl-4-methoxy-5-(6-(methylsulfonamido) naphthalen-2-yl)phenyl)acetamide; and (E)-N-(4-(5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-methoxy-3-(trifluoromethyl)styryl)phenyl)methanesulfonamide.
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Specification