PAR4 INHIBITOR THERAPY FOR PATIENTS WITH PAR4 POLYMORPHISM
First Claim
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1. A method of preventing or treating thrombosis in a human subject in need thereof, the method comprising administering a therapeutically effective amount of a PAR4 inhibitor to a human subject determined to have a “
- G”
allele for a single-nucleotide polymorphism (SNP) at rs773902.
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Abstract
Disclosed herein are methods for determining whether a PAR4 inhibitor should be administered to a human subject, the methods comprising administering a PAR4 inhibitor to a subject determined to have a “G” allele for a single-nucleotide polymorphism (SNP) at rs773902, and not administering a PAR4 inhibitor to a subject determined to have an “A” allele for the SNP at rs773902. A genotyping assay can be used to determine the SNP.
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20 Claims
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1. A method of preventing or treating thrombosis in a human subject in need thereof, the method comprising administering a therapeutically effective amount of a PAR4 inhibitor to a human subject determined to have a “
- G”
allele for a single-nucleotide polymorphism (SNP) at rs773902. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- G”
-
9. A method of preventing or treating thrombosis in a human subject who is (a) being administered a P2Y12 inhibitor and (b) has a “
- G”
allele for a single-nucleotide polymorphism (SNP) at rs773902;
the method comprising (a) stopping administration of the P2Y12 inhibitor and (b) administering a therapeutically effective amount of a PAR4 inhibitor. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
- G”
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17. A method of preventing or treating thrombosis in a human subject comprising:
- (a) subjecting a test sample obtained from the human subject to a genotyping assay adapted to determine the genotype of the SNP at rs773902;
(b) determining whether the polymorphism at rs773902 has a “
G”
allele or an “
A”
allele, and (c) administering to a patient having a “
G allele a PAR4 inhibitor and administering to said patient with the “
A”
allele a therapeutic that is not a PAR4 inhibitor. - View Dependent Claims (18, 19, 20)
- (a) subjecting a test sample obtained from the human subject to a genotyping assay adapted to determine the genotype of the SNP at rs773902;
Specification