AUTOMATIC RESPONSE/LIGHT MEASUREMENT DEVICE AND METHOD THEREFOR

• US 20170058322A1
• Filed: 09/13/2016
• Published: 03/02/2017
• Est. Priority Date: 02/04/2011
• Status: Active Grant

• Current Assignee: Universal Bio Research Co., Ltd (Precision System Science Co., Ltd)
• Original Assignee: Universal Bio Research Co., Ltd (Precision System Science Co., Ltd)
• Inventors: Tajima, Hideji
• Granted Patent: US 10,472,672 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: B01L 2300/1805 Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
• CPC Class Codes: B01L 7/52 with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples amplification or hybridisation processes per se C12Q1/68; controlling sequential reactions for synthesis B01J19/0046
• CPC Class Codes: B01L 7/54 using spatial temperature gradients
• CPC Class Codes: C12Q 1/6848 characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
• CPC Class Codes: C12Q 1/686 Polymerase chain reaction [PCR]
• CPC Class Codes: G01N 2021/6421 Measuring at two or more wavelengths
• CPC Class Codes: G01N 2021/6439 with indicators, stains, dyes, tags, labels, marks
• CPC Class Codes: G01N 2035/00366 Several different temperatures used
• CPC Class Codes: G01N 2035/00376 Conductive heating, e.g. heated plates
• CPC Class Codes: G01N 2035/103 using disposable tips
• CPC Class Codes: G01N 2035/1076 plurality or independently movable heads
• CPC Class Codes: G01N 21/13 Moving of cuvettes or solid samples to or from the investigating station handling materials for automatic analysis G01N35/00
• CPC Class Codes: G01N 21/31 Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry G01N21/72 takes precedence
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 21/6452 Individual samples arranged in a regular 2D-array, e.g. multiwell plates
• CPC Class Codes: G01N 2201/08 Optical fibres; light guides
• CPC Class Codes: G01N 2203/0226 High temperature; Heating means
• CPC Class Codes: G01N 35/0098 involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation magnetic particles used in immunoassays G01N33/54326; magnetic separation in general B03C
• CPC Class Codes: G01N 35/10 Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices G01N35/0099 takes precedence
• CPC Class Codes: G01N 35/1065 Multiple transfer devices

Abstract

The invention relates to an automatic response/light measurement device and a method therefor, and the purpose is to effectively and quickly perform an optical measurement relating to a reaction with high reliability without increasing a device size. The device is configured to have: a container group in which a plurality of reaction containers are arranged; a measurement mount provided with a plurality of coupling ends that are joinable with apertures of the reaction containers, and have light guide portions that optically connect with the interior of the joined reaction containers; a mount transfer mechanism; a measuring device having a measuring end having at least one light guide portion that is optically connectable to the light guide portions of the coupling ends, that is able to receive light based on an optical state within the reaction containers; an on-mount measuring end transfer mechanism; and a measurement control portion.

Claims

1. An automatic response/light measurement device comprising:

a container group in which two or more reaction containers are arranged;

a plurality of types of specific wavelength measuring devices provided with measuring ends having light guide portions that are optically connectable with the interior of said reaction containers, and that are able to receive light of specific wavelengths or specific wavelength bands based on an optical state within said reaction containers via the measuring ends;

a measuring end bundling portion that bundles the plurality of measuring ends in parallel;

a measuring end transfer mechanism that makes the bundled measuring ends relatively movable with respect to said container group; and

a measurement control portion that, by moving said measuring ends along a movement path that successively passes apertures of said reaction containers, controls said measuring end transfer mechanism such that light guide portions of said measuring ends and the interior of said reaction containers are successively optically connected, and, with respect to said specific wavelength measuring devices, instructs a measurement by receiving light of said specific wavelengths or specific wavelength bands based on an optical state within said reaction containers.

2. An automatic response/light measurement device according to claim 1, further comprising a measurement mount provided with two or more coupling ends that are directly or indirectly joinable with the apertures of said reaction containers, and that have light guide portions that optically connect with the interior of the joined reaction containers, wherein the measuring ends of said specific wavelength measuring device are provided on said mount, and in addition, said measuring end transfer mechanism has a mount transfer mechanism that makes said mount relatively movable with respect to said container group, and an on-mount measuring end transfer mechanism that makes the measuring ends of said specific wavelength measuring device movable in parallel on said mount.