Method and System for Treating Gastro-Esophageal Reflux Disease (GERD)
First Claim
1. A method for reducing the likelihood of GERD in an individual, comprising:
- administering to an individual an amount of H. pylori modified by a CRISPR-Cas or Cpf1 system to render H. pylori more susceptible to antibiotics;
permitting said modified H. pylori to become the dominant population of H. Pylori in the individual'"'"'s stomach; and
administering an effective amount of an antibiotic effective to kill the modified H.
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Accused Products
Abstract
A system and method for reducing the likelihood of GERD includes the modification of an individual'"'"'s gut microbes in a manner that reduces, if not eliminates, the symptoms of GERD. Certain embodiments employ Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated system (CRISPR-Cas) or Clustered Regularly Interspaced Short Palindromic Repeats from Prevotella and Francisella 1 (CRISPR/Cpf1) system to render H. Pylori more susceptible to certain drugs, including antibiotics, thus addressing the antibiotic resistance otherwise experienced by treating H. Pylori with antibiotics.
6 Citations
5 Claims
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1. A method for reducing the likelihood of GERD in an individual, comprising:
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administering to an individual an amount of H. pylori modified by a CRISPR-Cas or Cpf1 system to render H. pylori more susceptible to antibiotics; permitting said modified H. pylori to become the dominant population of H. Pylori in the individual'"'"'s stomach; and administering an effective amount of an antibiotic effective to kill the modified H. - View Dependent Claims (2, 3, 4, 5)
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Specification