METHOD AND APPARATUS FOR LIGHT-ACTIVATED DRUG THERAPY
First Claim
1. A transurethral light activated drug therapy device for the treatment of prostate conditions comprising:
- an elongated support member configured to pass through the urethra, the elongated support member having a proximal end and a distal end;
a light delivery device having a light generator along the support member and a light emitting region configured to be positioned within the urethra at least proximate to a treatment site, wherein the light generator is configured to generate light at a preselected wavelength or waveband in the range of an activation waveband of a photoactive composition; and
a positioning element carried by the support member, wherein the positioning element is configured to locate the support member within the urethra; and
wherein the support member is a catheter having at least one lumen and a selective coating to control where light transmits to the prostatic tissue.
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Accused Products
Abstract
A prostate treatment system having a light delivery device positionable in a transurethral device for treatment of benign prostatic hyperplasia (BPH). The light delivery device includes light generator, such as light emitting diodes (LED), laser diodes (LDs) or a diffusion quartz fiber tip connected to a light generator or a light emitting polymer which produces light at a selected wavelength or waveband or alternative sources of suitable light energy. The treatment device may further include a temperature monitoring system for monitoring the temperature at the treatment site. A light-activated drug is administered to the treatment site prior to light activation. The light-activated drug therapy induces cell death of the target tissue. The device provides a minimally invasive transurethral method for treatment of BPH or prostate cancer.
25 Citations
16 Claims
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1. A transurethral light activated drug therapy device for the treatment of prostate conditions comprising:
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an elongated support member configured to pass through the urethra, the elongated support member having a proximal end and a distal end; a light delivery device having a light generator along the support member and a light emitting region configured to be positioned within the urethra at least proximate to a treatment site, wherein the light generator is configured to generate light at a preselected wavelength or waveband in the range of an activation waveband of a photoactive composition; and a positioning element carried by the support member, wherein the positioning element is configured to locate the support member within the urethra; and wherein the support member is a catheter having at least one lumen and a selective coating to control where light transmits to the prostatic tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A transurethral light-activate drug therapy system for the treatment of prostate conditions in a male animal having an enlarged prostate, comprising:
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a photoreactive agent comprising mono-L-aspartyl chlorine e6; and a transurethral light activate drug therapy device comprising; a flexible elongated support member configured to pass through a urethra of the male animal, the elongated support member having a proximal end and a distal end; at least one longitudinal internal lumen through a majority of a length of the elongated support member; a light delivery device having a light generator carried by a distal region of the support member and located within the lumen, the light generator and a light emitting region are configured to be positioned within the urethra to deliver light to the prostate, wherein the light generator is configured to generate a light band with a peak at a preselected wavelength of about 664 nm radially at 360 degrees; a power source external to the support member, in flexible electrical communication with the light generator; and a positioning element carried by the support member, wherein; the positioning element is configured to locate the support member within the urethra; a majority of the portion of the support member inserted into the urethra of the male animal does not permit light from the light generator to pass through; a transparent or translucent, integral window along a portion of the length of the support member that is proximate to the prostate when the distal end of the support member is positioned in the bladder of the male animal and allows light from the light generator to pass through the window, and the window extends 360 degrees radially from the support member; the length of the light generator is at least as long as a majority of the length of the window; a majority of the length of the light generator is fixed in place within the window; when the support member is completely removed from the urethra, the light generator is completely removed from the urethra; and the support member is a catheter and comprises a selective coating to form the window to control where light transmits to the prostatic tissue.
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Specification