Combination Therapy with Peptide Epoxyketones
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Abstract
The invention provides combination therapy, wherein one or more other therapeutic agents are administered agents are administered with peptide epoxyketones or a pharmaceutically acceptable salt thereof. Another aspect of the invention relates to treating cancer with a peptide epoxyketone administered in combination with another therapeutic agent.
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Citations
59 Claims
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1-43. -43. (canceled)
- 44. A method for treating multiple myeloma, the method comprising administering to a patient, a combination regimen comprising (1) a peptide epoxyketone proteasome inhibitor having the structure of
- 50. A method for treating multiple myeloma, the method consisting essentially of administering to a patient, a combination regimen comprising, (1) a peptide epoxyketone proteasome inhibitor having the structure of
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54. A method of treating multiple myeloma, a solid tumor, a lymphoma or a leukemia form of cancer in a patient, the method comprising administering to the patient in need of treatment a combination of:
- (a) melphalan, and (b) an effective amount of an epoxy ketone proteasome inhibitor having the structure of
- View Dependent Claims (55, 56, 57, 58, 59)
Specification