METHODS AND DEVICES FOR THE DIAGNOSIS AND TREATMENT OF DIABETES

• US 20170172469A1
• Filed: 03/06/2017
• Published: 06/22/2017
• Est. Priority Date: 08/15/2008
• Status: Active Grant

• Current Assignee: Theranova, Llc
• Original Assignee: Theranova, Llc
• Inventors: LUXON, Evan S., BURNETT, Daniel R., HAMILTON, Marcie, NEIL, Brian M., MENSH, Brett D.
• Granted Patent: US 10,143,408 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 2005/1403 Flushing or purging
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

Methods and devices for the diagnosis and treatment of diabetes are disclosed in which an analyte concentration within a peritoneal fluid of a human subject may be determined by implanting an analyte sensor apparatus in the subject where the apparatus may comprise a housing and a flexible sensing catheter which has a lumen with a plurality of apertures and an exterior surface with an analyte sensor affixed thereto. The catheter may comprise a proximal end attached to the housing and the remaining end may be positioned freely within the peritoneal space to contact peritoneal fluid where an analyte concentration in the peritoneal fluid may be sensed. The housing may be anchored at a subcutaneous site proximate the peritoneal space. The sensed analyte concentration may then be transduced into a transmittable electrical signal.

Claims

1. A method of determining an analyte concentration within a peritoneal fluid of a human subject, comprising:

implanting an analyte sensor apparatus in the subject, the apparatus comprising a flexible sensing catheter and a housing, the catheter comprising a lumen with a plurality of apertures and an exterior surface with an analyte sensor affixed thereto, the catheter comprising a proximal end attached to the housing, wherein the implanting step comprises positioning the sensing catheter freely within the peritoneal space and anchoring the housing at a subcutaneous site proximate the peritoneal space;

contacting the analyte sensor with a peritoneal fluid sample outside the sensing catheter;

sensing an analyte concentration in peritoneal fluid sample; and

transducing the sensed analyte concentration into a transmittable electrical signal.

2. A method of determining an analyte concentration within a peritoneal fluid of a human subject, comprising:

inserting a flexible sensing catheter into a peritoneum, the catheter comprising a lumen with a plurality of apertures and an exterior surface with an analyte sensor affixed thereto, the catheter comprising a proximal end attached to the housing, wherein inserting comprises positioning the sensing catheter freely within the peritoneal space, tunneling the proximate end through the subcutaneous space and attaching the proximal end to a sensing apparatus outside of the body;

contacting the analyte sensor with a peritoneal fluid sample outside the sensing catheter;

sensing an analyte concentration in peritoneal fluid sample; and

transducing the sensed analyte concentration into an electrical signal outside of the body.