Immobilization of an Active Agent on a Substrate
First Claim
1. A method of immobilizing an active agent on a substrate surface, comprising the steps of:
- depositing a primer compound on a substrate, thereby forming a primed substrate;
contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate; and
contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby forming a substrate with an active agent immobilized on the surface thereof.
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Accused Products
Abstract
The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.
5 Citations
23 Claims
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1. A method of immobilizing an active agent on a substrate surface, comprising the steps of:
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depositing a primer compound on a substrate, thereby forming a primed substrate; contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate; and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby forming a substrate with an active agent immobilized on the surface thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of immobilizing an active agent on a substrate surface, comprising the steps of:
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depositing a primer compound on the substrate thereby forming a primed substrate; combining in solution a compound including a trihydroxyphenyl group and an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate; and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby coupling the trihydroxyphenyl group of the active agent-trihydroxyphenyl conjugate to the primed substrate and forming a substrate with an active agent immobilized on the surface thereof. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification