MICRONEEDLE COMPOSITIONS AND METHODS OF USING SAME
First Claim
Patent Images
1. A microneedle device for administering an RNA molecule, comprising:
- (a) a substrate comprising a plurality of microneedles; and
(b) a composition comprising an RNA encoding an exogenous polypeptide coated onto or embedded into the plurality of microneedles.
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Accused Products
Abstract
Described herein, are microneedle devices comprising a recombinant alphavirus replicon encoding an exogenous polypeptide, wherein the recombinant alphavirus replicon is coated onto or embedded into a plurality of microneedles. Also described herein are methods of preparing a microneedle device comprising a recombinant alphavirus replicon encoding an exogenous polypeptide. Also disclosed herein are methods of inducing an immune response in an individual comprising contacting the individual with a microneedle device comprising a recombinant alphavirus replicon encoding an exogenous polypeptide.
3 Citations
47 Claims
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1. A microneedle device for administering an RNA molecule, comprising:
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(a) a substrate comprising a plurality of microneedles; and (b) a composition comprising an RNA encoding an exogenous polypeptide coated onto or embedded into the plurality of microneedles. - View Dependent Claims (2, 3, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 35, 36, 37, 38, 39, 40, 41, 44, 45)
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4. (canceled)
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5. (canceled)
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6. (canceled)
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22-34. -34. (canceled)
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42. The microneedle of clam 40, wherein the fluorinating agent is heptafluoro butyric acid anhydride.
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43. The microneedle of clam 40, wherein the amino acid is arginine or histidine.
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46. A microneedle device for administering an RNA molecule, comprising:
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(a) a substrate comprising a plurality of microneedles; and (b) a pharmaceutical composition comprising a recombinant alphavirus replicon encoding an exogenous polypeptide and a pharmaceutically acceptable carrier or excipient coated onto or embedded into the plurality of microneedles.
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47-97. -97. (canceled)
Specification