SYSTEMS AND METHODS FOR PROCESSING ANALYTE SENSOR DATA

• US 20170273606A1
• Filed: 06/13/2017
• Published: 09/28/2017
• Est. Priority Date: 03/16/2012
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Estes, Michael J., Vanslyke, Stephen J., Kamath, Apurv Ullas, Peyser, Thomas A., Bohnett, Lucas, Mahalingam, Aarthi, Garcia, Arturo, Simpson, Peter C., Davis, Anna Leigh, Bhm, Sebastian
• Granted Patent: US 10,987,040 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2562/02 Details of sensors specially adapted for in-vivo measurements
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: G01D 3/022 having an ideal characteristic, map or correction data stored in a digital memory
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously.

Claims

1. A method for processing sensor data of a continuous analyte sensor implanted within a body, comprising:

initializing the sensor;

applying a first set of time-dependent algorithmic functions to data associated with the sensor during a first interval based on a first elapsed time since the sensor was implanted; and

applying a second set of time-dependent algorithmic functions to the data associated with the sensor during a second interval after the first interval based on a second elapsed time since the sensor was implanted.

2. The method of claim 1, wherein initializing the sensor comprises engaging electronics associated with the sensor with a housing.

3. The method of claim 2, wherein engagement of the electronics with the receiving unit is detected and initialization commences automatically upon detection of the engagement.

4. The method of claim 1, further comprising determining whether the sensor has been previously used.

5. The method of claim 4, wherein determining whether the sensor has been previously used comprises comparing a conversion function of the sensor with a conversion function of a previously removed sensor.

6. The method of claim 4, wherein determining whether the sensor has been previously used comprises reading a raw signal of the sensor.

7. The method of claim 4, wherein determining whether the sensor has been previously used comprises comparing a sensitivity and/or baseline of the sensor with a sensitivity and/or baseline of a previously removed sensor.

8. The method of claim 4, wherein determining whether the sensor has been previously used comprises comparing a trend in a signal from the sensor with a trend in a signal from a previously removed sensor.

9. The method of claim 4, wherein determining whether the sensor has been previously used comprises performing two or more independent tests and then determining a probability that the sensor has been previously used based upon results of the tests.

10. The method of claim 1, wherein applying the first set of time-dependent algorithmic functions comprises applying drift compensation to the data associated with the sensor.

11. The method of claim 1, wherein the first and second set of time-dependent algorithmic functions comprise first and second boundaries of acceptability.

12. The method of claim 11, wherein the first boundary comprises a first sensitivity value and the second boundary comprises a second sensitivity value.

13. The method of claim 11, wherein the first boundary comprises a first baseline value and the second boundary comprises a second baseline value.

14. The method of claim 11, wherein the first boundary comprises a first drift rate of the sensitivity over a time period and the second boundary comprises a second drift rate of the sensitivity over time.

15. The method of claim 11, wherein the first boundary comprises a first drift rate of the baseline over a time period and the second boundary comprises second drift rate of the baseline over time.

16. The method of claim 11, wherein the first boundary delineates acceptable slopes and baselines of a conversion function and the second boundary delineates acceptable slopes and baselines of the conversion function.

17. The method of claim 1, wherein the first and second set of time-dependent algorithmic functions comprise first and second parameters associated with the conversion function.

18. The method of claim 1, wherein the wherein the first and second set of time-dependent algorithmic functions comprise first and second drift compensation functions.

19. The method of claim 18, wherein the first and second drift compensation functions differ in the amount of drift compensation that they apply.

20. A system for processing sensor data of a continuous analyte sensor implanted within a body, comprising:

a continuous analyte sensor configured to be implanted within a body; and

sensor electronics configured to receive and process sensor data output by the sensor, the sensor electronics including a processor configured to

initialize the sensor;

apply a first set of time-dependent algorithmic functions to an data associated with the sensor during a first interval based on a first elapsed time since the sensor was implanted; and

apply a second set of time-dependent algorithmic functions to the data associated with the sensor during a second interval after the first interval based on a second elapsed time since the sensor was implanted.