COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS
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Accused Products
Abstract
Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
4 Citations
61 Claims
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1-30. -30. (canceled)
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31. A method for treating obesity in a subject in need thereof comprising:
a) administering a composition comprising; i. at least about 500 mg of leucine and/or at least about 200 mg of one or more metabolites thereof, wherein the one or more leucine metabolites are selected from the group consisting of keto-isocaproic acid (KIC), alpha-hydroxy-isocaproic acid, and HMB; and ii. an amount of at least about 0.5 mg of a sirtuin pathway activator, - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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61. A method for reducing body weight or weight gain in a subject in need thereof comprising administering an effective amount of leucine and/or one or more metabolites thereof, and a sirtuin pathway activator.
Specification