ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS
1 Assignment
0 Petitions
Accused Products
Abstract
1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.
-
Citations
40 Claims
-
1-19. -19. (canceled)
- 20. A compound of the formula:
- 23. A compound of the formula:
- 26. A compound of the formula:
-
29. A method of preparing a heterocyclic compound, the method comprising:
-
combining at least one alkyne with at least one 1,3-dipole-functional compound selected from the group consisting of an azide-functional compound, a nitrile oxide-functional compound, a nitrone-functional compound, an azoxy-functional compound, an acyl diazo-functional compound, and combinations thereof; and allowing the at least one 1,3-dipole-functional compound and the at least one alkyne to react under conditions effective to form the heterocyclic compound; wherein the alkyne is of the formula; - View Dependent Claims (30, 31, 32, 33, 34, 35, 36)
-
- 37. A compound of the formula:
Specification