METHODS AND COMPOSITIONS FOR DETECTING FUNGI AND MYCOTOXINS
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Abstract
The invention relates to a method of identifying a specific fungal species in patient tissue or body fluid. The method comprises the steps of extracting and recovering DNA of the fungal species from the patient tissue or body fluid, amplifying the DNA, hybridizing a probe to the DNA to specifically identify the fungal species, and specifically identifying the fungal species. The invention also relates to a method of identifying a mycotoxin in patient tissue or body fluid. The method comprises the steps of extracting and recovering the mycotoxin from the patient tissue or body fluid, contacting the mycotoxin with an antibody directed against the mycotoxin, and identifying the myocotoxin. Both of these methods can be used to determine if a patient is at risk for or has developed a disease state related to a fungal infection, and to develop an effective treatment regimen for the patient.
3 Citations
70 Claims
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1-58. -58. (canceled)
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59. A method of quantifying a mycotoxin in a patient tissue or a body fluid, the method comprising:
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extracting and recovering the mycotoxin from the patient tissue or the body fluid, wherein the mycotoxin is a tricothecene mycotoxin, wherein the body fluid is selected from the group consisting of a urine sample, a nasal secretion sample, a nasal wash sample, and a sputum sample, and wherein the patient has been exposed to mold; and quantifying the mycotoxin to determine whether the patient has a fungal infection that produces the mycotoxin, wherein the method detects 0.2 ng/ml of the tricothecene mycotoxin. - View Dependent Claims (60, 61, 62, 63, 64)
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65. A method of determining if a patient is at risk for or has developed a disease state related to a fungal infection that produces a mycotoxin, the method comprising:
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extracting and recovering the mycotoxin from a tissue or a body fluid of the patient, wherein the mycotoxin is a tricothecene mycotoxin, wherein the body fluid is selected from the group consisting of a urine sample, a nasal secretion sample, a nasal wash sample, and a sputum sample, and wherein the patient has been exposed to mold; and quantifying the mycotoxin to determine if the patient is at risk for or has developed the disease state related to the fungal infection that produces the mycotoxin, wherein the method detects 0.2 ng/ml of the tricothecene mycotoxin. - View Dependent Claims (66, 67, 68, 69, 70)
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Specification