DECARBOXYLATED CANNABIS RESINS, USES THEREOF AND METHODS OF MAKING SAME

• US 20180000857A1
• Filed: 06/29/2017
• Published: 01/04/2018
• Est. Priority Date: 06/29/2016
• Status: Active Grant

• Current Assignee: CannScience Innovations Inc.
• Original Assignee: CannScience Innovations Inc.
• Inventors: Kotra, Lakshmi Premakanth, Lewis, Melissa Maureen, Wasilewski, Ewa, Grover, Har
• Granted Patent: US 10,143,706 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 2236/00 Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 31/775 Phenolic resins
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: B01D 11/0211 in combination with an electric or magnetic field
• CPC Class Codes: B01D 11/0265 Applying ultrasound
• CPC Class Codes: B01D 11/0288 Applications, solvents
• CPC Class Codes: G01N 2030/027 Liquid chromatography
• CPC Class Codes: G01N 30/02 Column chromatography

Abstract

The disclosure relates to decarboxylated cannabis resins and methods of making the decarboxylated cannabis resins by extraction and decarboxylation of cannabinoids from Cannabis species using microwaves and solvents. The disclosure also relates to use of the decarboxylated cannabis resins for making pharmaceutical products comprising same.

Claims

1. A decarboxylated cannabis resin, wherein the resin comprises decarboxylated cannabinoids from a Cannabis spp. plant, such that Δ

9-tetrahydrocannabidiolic acid (Δ

9-THCA) and cannabidiolic acid (CBDA) cannabinoids in the plant are each independently 90% to 100% decarboxylated to yield Δ

9-tetrahydrocannabinol (THC) and cannabidiol (CBD) respectively in the resin.

2. The decarboxylated cannabis resin of claim 1, wherein the resin further comprises cannabinol (CBN).

3. The decarboxylated cannabis resin of claim 1, where the resin is substantially free of solvent.

4. A pharmaceutical product comprising (i) the decarboxylated cannabis resin of claim 1 and (ii) a suitable pharmaceutically acceptable carrier or excipient.

5. A natural health product comprising the decarboxylated cannabis resin of claim 1.

6. A method of extracting and decarboxylating cannabinoids from cannabis plant material, the method comprising:

(i) extracting cannabinoids from the cannabis plant material by contacting the cannabis plant material with a solvent to extract cannabinoids from the cannabis plant material, the extract of cannabis comprising the solvent and cannabinoids; and

(ii) decarboxylating the cannabinoids in (a) the plant material and (b) the extract comprising cannabinoids by subjecting the plant material and extract to microwaves at temperature of about 100-200°

C. in a sealed container or sealed vessel and for a time period sufficient to form the corresponding decarboxylated cannabinoids in the extract.

7. The method of claim 6, wherein before the step of extracting, the plant material is broken down to form cannabis plant material of a size and form suitable for extraction.

8. The method of claim 6, wherein the extracting and decarboxylating occur concurrently.

9. The method of claim 6, wherein the cannabis plant material is suspended in the solvent by stirring or agitation and wherein the solvent is selected from the group of solvents consisting of:

80-100% ethanol, ethylene glycol, isopropanol, and a combination of any of the above.

10. The method of claim 6, where the ratio of solvent to cannabis plant material is such that the cannabis plant material is submerged in the solvent in the sealed container.

11. The method of claim 6, wherein the time period is about 15-75 minutes depending on scale of the reaction and wherein the temperature is about 130°

C. to about 180°

C., or the temperature is about 150°

C. to about 170°

C.

12. The method of claim 6, wherein the microwaves have a frequency of about 2.45 GHz and a wavelength of about 1.22×

10⁸ nm.

13. The method of claim 6, wherein subjecting the plant material and extract to microwaves in the sealed container or sealed vessel occurs under pressure of about 2-22 bar.

14. The method of claim 6, wherein the extracted and decarboxylated cannabinoids are recovered in the form of a cannabis resin.

15. The method of claim 6, wherein the extracted and decarboxylated cannabinoids are recovered in the form of isolated compounds.

16. The method of claim 14, wherein the decarboxylated cannabinoids in the resin are subjected to winterization for the removal of waxes.

17. The method of claim 7, wherein prior to the step where the plant material is broken down, the plant material is dried.

18. The method of claim 6, further comprising a step of removing the solvent from the resin to obtain a substantially solvent-free decarboxylated cannabis resin.

19. The method of claim 6, wherein the cannabis plant material is trichomes, cannabis female inflorescence, flower bract, cannabis stalk, cannabis leaf, or multiples or combinations thereof.

20. The method of claim 6, wherein the solvent is removed from the resin.