Composition and Method for Improving Sleep Duration and Quality

• US 20180021411A1
• Filed: 06/16/2017
• Published: 01/25/2018
• Est. Priority Date: 07/20/2016
• Status: Active Grant

• Current Assignee: Board of Supervisors of Louisiana State University Agricultural & Mechanical College (Louisiana State University System)
• Original Assignee: Board of Supervisors of Louisiana State University Agricultural & Mechanical College (Louisiana State University System)
• Inventors: Losso, Jack N., Estrada Andino, Jose Daniel
• Granted Patent: US 10,376,566 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/191 having two or more hydroxy groups, e.g. gluconic acid
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/28 Compounds containing heavy metals
• CPC Class Codes: A61K 31/343 condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
• CPC Class Codes: A61K 31/353 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• CPC Class Codes: A61K 31/365 Lactones
• CPC Class Codes: A61K 31/728 Hyaluronic acid
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]

Abstract

An intervention for sleep disorders comprises: collagen, a gelatin peptide, or the amino acid glycine; L-theanine; lactucopicrin, deoxylactucopicrin, or another lactucopicrin derivative; hyaluronic acid; epigallocatechin gallate; and quinic acid. The intervention helps regulate pro-inflammatory biomarkers that are often associated with insomnia development and progression. These biomarkers include cytokines and enzymes associated with tryptophan degradation. Inhibition of these enzymes and cytokines improves tryptophan availability and sleep quality, and allows individuals to sleep better with fewer side effects. The composition promotes high-quality, deep sleep.

Claims

1. A composition comprising:

(a) a first component selected from one or more of the following;

collagen, a gelatin peptide, or the amino acid glycine;

wherein said first component has a molecular weight less than 3500 Dalton;

(b) a second component comprising L-theanine;

(c) a third component comprising lactucopicrin, deoxylactucopicrin, or another lactucopicrin derivative;

(d) a fourth component comprising hyaluronic acid;

(e) a fifth component comprising epigallocatechin gallate; and

(f) a sixth component comprising quinic acid.